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Titolo:
Differentiation of GABA(A) receptors in subcortical heterotopias: subunit distribution of displaced cortex reflects original commitment
Autore:
Hagemann, G; Fritschy, JM; Witte, OW; Redecker, C;
Indirizzi:
Univ Dusseldorf, Dept Neurol, Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany rf, Dept Neurol, Dusseldorf, Germany Univ Zurich, Inst Pharmacol & Toxicol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 icol, CH-8057 Zurich, Switzerland
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3413 - 3417
SICI:
0959-4965(20011116)12:16<3413:DOGRIS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL MIGRATION DISORDERS; FOCAL CORTICAL DYSPLASIAS; GABA(A)-RECEPTOR SUBTYPES; DEVELOPING BRAIN; RAT; CONNECTIONS; DYSGENESIS; MODEL; PET;
Keywords:
gamma-aminobutyric acid; cortical dysgenesis; epilepsy; microgyria; receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hagemann, G Univ Jena, Dept Neurol, Philosophenweg 3, D-07740 Jena, Germany Univ Jena Philosophenweg 3 Jena Germany D-07740 Jena, Germany
Citazione:
G. Hagemann et al., "Differentiation of GABA(A) receptors in subcortical heterotopias: subunit distribution of displaced cortex reflects original commitment", NEUROREPORT, 12(16), 2001, pp. 3413-3417

Abstract

Recent evidence suggests that the expression of GABAA receptor subunits isdetermined by an early innate program which can be further modified by thalamic input and local factors. We analyzed the GABAA subunit distribution in experimentally induced subcortical heterotopia which are a subgroup of neuronal migration disorders. Heterotopias. consist of clusters of neurons which have stopped migration early, before they have reached their final commitment and well before thalamic afferents have reached their targets. Immunohistochemical analyses of five important GABAA receptor subunits revealed an expression pattern typical for upper cortical layers reflecting the original commitment of the heterotopic neurons. These results point towards detailed innate determinants of cell fate which even contain information on receptor subunit distribution and are not affected by ectopic. positioning. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:22:14