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Titolo:
Modulation of brain gene expression during sleep and wakefulness: A reviewof recent findings
Autore:
Tononi, G; Cirelli, C;
Indirizzi:
Neurosci Inst, San Diego, CA 92121 USA Neurosci Inst San Diego CA USA 92121 urosci Inst, San Diego, CA 92121 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
, volume: 25, anno: 2001, supplemento:, 5
pagine: S28 - S35
SICI:
0893-133X(200111)25:<S28:MOBGED>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; C-FOS; RAT-BRAIN; LOCUS-COERULEUS; MESSENGER-RNA; WAKING CYCLE; NEURONS; DEPRIVATION;
Keywords:
sleep deprivation; microarray; differential display;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Cirelli, C Univ Wisconsin, Dept Psychiat, 6001 Res Pk Blvd, Madison, WI 53719 USA Univ Wisconsin 6001 Res Pk Blvd Madison WI USA 53719 53719 USA
Citazione:
G. Tononi e C. Cirelli, "Modulation of brain gene expression during sleep and wakefulness: A reviewof recent findings", NEUROPSYCH, 25, 2001, pp. S28-S35

Abstract

The characterization of the molecular correlates of sleep and wakefulness is essential to understand the restorative processes occurring during sleepand the cellular mechanisms underlying sleep regulation. In order to determine what molecular changes occur during the sleep-waking cycle, we have recently performed a systematic screening of gene expression in the brain of sleeping, sleep deprived, and spontaneously awake rates. Out of the similarto 10,000 genes screened so far, a small minority (similar to0.5%) was differentially expressed in the cerebral cortex across behavioral states. Mostgenes were upregulated in wakefulness and sleep deprivation relative to sleep, while only a few, were upregulated in sleep relative to wakefulness and sleep deprivation. Almost all the genes upregulated in sleep, and severalgenes upregulated in wakefulness and sleep deprivation, did not match any known sequence. Known genes expressed at higher levels in wakefulness and sleep deprivation could be grouped into functional categories: immediate early genes transcription factors, genes related to energy metabolism, growth factors/adhesion molecules, chaperones/heat shock proteins, vesicle and synapse-related genes, neurotransmitter/hormone receptors, neurotransmitter transporters, enzymes, and others. Although the characterization of the molecular correlates of sleep, wakefulness, and sleep deprivation is still in progress, it is already apparent that the transition from sleep to waking canaffect basic cellular functions such as RNA and protein synthesis, neural plasticity, neurotransmission, and metabolism. (C) 2001 American College ofNeuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:11:18