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Titolo:
Contributions of PET and SPECT to the understanding of the pathophysiologyof Parkinson's disease
Autore:
Thobois, S; Guillouet, S; Broussolle, E;
Indirizzi:
CERMEP, Lyon, France CERMEP Lyon FranceCERMEP, Lyon, France Hop Neurol Pierre Wertheimer, Serv Neurol D, Lyon, France Hop Neurol Pierre Wertheimer Lyon France r, Serv Neurol D, Lyon, France
Titolo Testata:
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
fascicolo: 5, volume: 31, anno: 2001,
pagine: 321 - 340
SICI:
0987-7053(200110)31:5<321:COPAST>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; DOPA-RESPONSIVE DYSTONIA; CEREBRAL BLOOD-FLOW; RICHARDSON-OLSZEWSKI SYNDROME; SUPPLEMENTARY MOTOR AREA; BASAL GANGLIONIC DEGENERATION; LONG-TERM TREATMENT; I-123 BETA-CIT;
Keywords:
activation; caudate nucleus; cerebral blood flow (rCBF); cerebral metabolism; dopamine; Parkinson's disease; parkinsonism; positron emission tomography (PET); putamen; regional; single photon emission computed tomography (SPECT); striatum; [F-18]-fluoro-L-Dopa; [C-11]-Raclopride; [O-15]-H2O; [F-18]-desoxyglucose; [123]-beta-CIT; [I-123]-FP-beta-CIT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
160
Recensione:
Indirizzi per estratti:
Indirizzo: Broussolle, E CERMEP, 59,Blvd Pinel, Lyon, France CERMEP 59,Blvd Pinel Lyon France ,Blvd Pinel, Lyon, France
Citazione:
S. Thobois et al., "Contributions of PET and SPECT to the understanding of the pathophysiologyof Parkinson's disease", NEUROP CLIN, 31(5), 2001, pp. 321-340

Abstract

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) provide the means to studying in vivo the neurochemical, hemodynamic or metabolic consequences of the degeneration of the nigrostriatal dopaminergic system in Parkinson's disease (PD). The extent of striatal dopaminergic denervation. can be quantified with radiotracers as [F-18]FDopafor PET and [I-123]tropanes for SPECT. There are other radiotracers such as [C-11]Dopa and meta-tyrosines as well as PET tracers for uptake sites, Striatal uptake of [18F]FDopa and [I-123]tropanes is markedly decreased in PD, more in the putamen than in the caudate nucleus, and inversely correlateswith the severity of motor signs and with duration of disease. PET and SPECT make possible the assessment by noninvasive means of the changes in dopamine receptor density, the effect of neuronal transplants or neuroprotective treatments in PD patients, or the nigrostriatal dopaminergic function in at-risk subjects. Activation studies using cerebral blood flow and metabolism measurements during a motor task reveal an impaired ability to activate the supplementary motor area and dorsolateral prefrontal cortex in PD. Thisfunctional disability is reversed by the use of dopaminergic medication orby surgical treatment by pallidotomy or deep brain stimulation. The differential diagnosis between PD and multiple system atrophy, progressive supranuclear palsy or corticobasal degeneration is not yet clearly established byPET and SPECT, even though these syndromes have some particular neurochemical and metabolic profiles. On the other hand, PET and SPECT are useful fordistinguishing PD from Dopa-responsive dystonia, or for assessing the integrity of the nigrostriatal dopaminergic pathway in atypical cases of postural tremor or iatrogenic parkinsonian syndromes. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:24:08