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Titolo:
An electrophysiological characterisation of long-term potentiation in cultured dissociated hippocampal neurones
Autore:
Fitzjohn, SM; Pickard, L; Duckworth, JK; Molnar, E; Henley, JM; Collingridge, GL; Noel, J;
Indirizzi:
Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 6, volume: 41, anno: 2001,
pagine: 693 - 699
SICI:
0028-3908(200111)41:6<693:AECOLP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT FOLLOWING STIMULATION; MINIATURE SYNAPTIC CURRENTS; SILENT SYNAPSES; NMDA RECEPTOR; LASTING POTENTIATION; PERFORANT PATH; DENTATE AREA; LTP; ACTIVATION; INDUCTION;
Keywords:
long-term potentiation; N-methyl-D-aspartate; hippocampus; neuronal culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Collingridge, GL Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Univ Walk, Bristol BS8 1TD, Avon, England Univ Bristol Univ Walk BristolAvon England BS8 1TD gland
Citazione:
S.M. Fitzjohn et al., "An electrophysiological characterisation of long-term potentiation in cultured dissociated hippocampal neurones", NEUROPHARM, 41(6), 2001, pp. 693-699

Abstract

Long-term potentiation (LTP) of synaptic transmission is under intense investigation. It is believed that the mechanisms involved in its induction and expression are critically involved in synaptic processes that are important for teaming and memory and other physiological functions. A reliable means of inducing LTP in dissociated cultured neurones would facilitate investigations into the molecular basis of LTP but has been hard to achieve. Herewe report a mechanism for inducing LTP in postnatal dissociated hippocampal neurones using transient depolarisation. This form of LTP is prevented byNMDA receptor antagonists and by chelating Call in the postsynaptic neurone. It is manifest primarily as an increase in the frequency of mEPSCs. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:09:33