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Titolo:
Functional changes in the inhibitory effect of spinal cannabinoid (CB) receptor activation in nerve injured rats
Autore:
Chapman, V;
Indirizzi:
Univ Nottingham, Sch Med, Sch Biomed Sci, Queens Med Ctr, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 7, volume: 41, anno: 2001,
pagine: 870 - 877
SICI:
0028-3908(200112)41:7<870:FCITIE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMIC-RANGE NEURONS; MU-OPIOID RECEPTORS; LUMBAR DORSAL HORN; NEUROPATHIC PAIN; EVOKED ACTIVITY; CORD; LOCALIZATION; LIGATION; STIMULUS; BLOCKADE;
Keywords:
cannabinoid receptor; nerve injury; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chapman, V Univ Nottingham, Sch Med, Sch Biomed Sci, Queens Med Ctr, E Floor, Nottingham NG7 2UH, England Univ Nottingham E Floor Nottingham EnglandNG7 2UH UH, England
Citazione:
V. Chapman, "Functional changes in the inhibitory effect of spinal cannabinoid (CB) receptor activation in nerve injured rats", NEUROPHARM, 41(7), 2001, pp. 870-877

Abstract

Recent interest has focused on the potential of cannabinoids as novel analgesics. The aim of the present Study was to investigate the effect of a potent cannabinoid agonist, HU210, on somatosensory transmission in a model ofneuropathic pain. Here, the effects of spinal versus systemic administration of HU210 on noxious and innocuous evoked responses of spinal neurones ofnerve injured (selective ligation of spinal nerves L5-L6) and sham operated rats were compared 14-17 days post-surgical intervention. Spinal administration of HU210 (0.5-500 ng/50 mul) significantly reduced the C-fibre mediated post-discharge response of spinal neurones in sham operated, but not nerve injured rats. By contrast, spinal HU210 significantly reduced A delta -fibre evoked responses of spinal neurones in both sham operated and nerve injured rats. Systemic administration of HU210 (6-60 mug/kg)significantly reduced C- and A delta -fibre evoked responses or spinal neurones in sham operated rats. HU210 (60 mug/kg) inhibited the overall C-fibre evoked response (54 +/-8% of control, p <0.01), post-discharge response (28 +/- 12% of control, p <0.01), and A delta -fibre evoked (48 5% of control p <0.01) responses of spinal neurones. In nerve injured rats, systemic administration of HU210 did not significantly reduce C- or A beta -fibre evoked responses of spinal neurones. This study demonstrates plasticity of the spinal cannabinoid receptor system following peripheral nerve injury. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:35:39