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Titolo:
Phosphorylation and local presynaptic protein synthesis in calcium- and calcineurin-dependent induction of crayfish long-term facilitation
Autore:
Beaumont, V; Zhong, N; Fletcher, R; Froemke, RC; Zucker, RS;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 urobiol, Berkeley, CA 94720 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 32, anno: 2001,
pagine: 489 - 501
SICI:
0896-6273(20011108)32:3<489:PALPPS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-PHASE LTP; NEUROMUSCULAR-JUNCTION; NERVE-TERMINALS; SYNAPTIC TRANSMISSION; TRANSMITTER RELEASE; GLUTAMATE RECEPTORS; HIPPOCAMPAL SLICES; MOTOR SYNAPSES; REQUIRING CAMP; VISUAL-CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Beaumont, V MRC, Mol Biol Lab, Div Neurobiol, Hills Rd, Cambridge CB2 2QH,England MRC Hills Rd Cambridge England CB2 2QH ridge CB2 2QH, England
Citazione:
V. Beaumont et al., "Phosphorylation and local presynaptic protein synthesis in calcium- and calcineurin-dependent induction of crayfish long-term facilitation", NEURON, 32(3), 2001, pp. 489-501

Abstract

Long-term facilitation at the crayfish opener muscle is elicited by prolonged high frequency stimulation, and arises from an increase in functional active zones, resulting in increased transmitter release. LTF induction depends critically upon presynaptic calcium accumulation and calcineurin (PP2B)activity. The protein synthesis dependence of this synaptic strengthening was investigated. LTF occurred without transcription, but the translation inhibitors cycloheximide and anisomycin, or local presynaptic injection of mRNA cap analog m(7)GpppG, impaired LTF expression. Both MAP kinase and phosphatidylinositol 3-OH kinase (PI3K) activation are implicated in this rapamycin-sensitive synaptic potentiation. This study defines an important role for protein synthesis in the expression of activity-dependent plasticity, and provides mechanistic insight for the induction of this process at presynaptic sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:29:24