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Titolo:
Pathological glial tau accumulations in neurodegenerative disease: review and case report
Autore:
Berry, RW; Quinn, B; Johnson, N; Cochran, EJ; Ghoshal, N; Binder, LI;
Indirizzi:
Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 & Mol Biol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Cognit Neurol & Alzheimers Dis Ctr, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 ers Dis Ctr, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pathol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Psychiat, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 pt Psychiat, Chicago, IL 60611 USA Rush Presbyterian St Lukes Med Ctr, Dept Pathol, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 5-6, volume: 39, anno: 2001,
pagine: 469 - 479
SICI:
0197-0186(200111/12)39:5-6<469:PGTAIN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; MICROTUBULE-ASSOCIATED PROTEIN; PAIRED HELICAL FILAMENTS; CENTRAL NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; CORTICOBASAL DEGENERATION; PICKS-DISEASE; FRONTOTEMPORAL DEMENTIA; PATHOGENETIC IMPLICATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Berry, RW Northwestern Univ, Sch Med, Dept Cell & Mol Biol, 303 E Chicago Ave, Chicago, IL 60611 USA Northwestern Univ 303 E Chicago Ave Chicago IL USA 60611 611 USA
Citazione:
R.W. Berry et al., "Pathological glial tau accumulations in neurodegenerative disease: review and case report", NEUROCHEM I, 39(5-6), 2001, pp. 469-479

Abstract

Abnormal deposits of tau protein accumulate in glia in many neurodegenerative diseases. This suggests that in some instances the disease process may target glial tau, with neuronal degeneration a secondary consequence of this process. In this report, we summarize the pattern of glial tau pathology in various neurodegenerative disorders and add original findings from a case of sporadic frontotemporal dementia that exhibits astrocytic tau pathology. The neurodegenerative diseases span the spectrum of relative neuronal and glial tau involvement, from disorders affecting only neuronal tau to those in which abnormal tau deposits are found only in glia. From this, we conclude that glial tau can be a primary target of the disease process, and that this can lead to neuronal degeneration. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:40:53