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Titolo:
Hyperbaric oxygen in the treatment of calciphylaxis: a case series
Autore:
Podymow, T; Wherrett, C; Burns, KD;
Indirizzi:
Ottawa Gen Hosp, Ottawa Hlth Res Inst, Kidney Res Ctr, Dept Med,Div Nephrol, Ottawa, ON K1H 8L6, Canada Ottawa Gen Hosp Ottawa ON Canada K1H 8L6 hrol, Ottawa, ON K1H 8L6, Canada Univ Ottawa, Ottawa Hosp, Dept Anesthesiol, Ottawa, ON K1H 8L6, Canada Univ Ottawa Ottawa ON Canada K1H 8L6 sthesiol, Ottawa, ON K1H 8L6, Canada
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 11, volume: 16, anno: 2001,
pagine: 2176 - 2180
SICI:
0931-0509(200111)16:11<2176:HOITTO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; CALCIFIC UREMIC ARTERIOLOPATHY; SMALL-ARTERY DISEASE; SKIN NECROSIS; PROXIMAL CALCIPHYLAXIS; MEDIAL CALCIFICATION; INTIMAL HYPERPLASIA; PARATHYROIDECTOMY; HEMODIALYSIS; CALCINOSIS;
Keywords:
calciphylaxis; dialysis; hyperbaric oxygen; renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Burns, KD Ottawa Gen Hosp, Ottawa Hlth Res Inst, Kidney Res Ctr, Dept Med,Div Nephrol, 501 Smyth Rd,LM-18, Ottawa, ON K1H 8L6, Canada Ottawa Gen Hosp501 Smyth Rd,LM-18 Ottawa ON Canada K1H 8L6 nada
Citazione:
T. Podymow et al., "Hyperbaric oxygen in the treatment of calciphylaxis: a case series", NEPH DIAL T, 16(11), 2001, pp. 2176-2180

Abstract

Background. Calciphylaxis, also referred to as calcific uraemic arteriolopathy, is a syndrome associated with end-stage renal disease (ESRD). and causes necrotic skin ulcers. often leading to a fatal outcome. Hyperbaric oxygen (HBO2) therapy has been used to enhance wound healing, but its role in the treatment of calciphylaxis is unclear. Methods. We undertook a retrospective study of patients oil renal replacement therapy with biopsy-proven calciphylaxis who were treated with HBO2 between March 1997 and February 2000. Results. Five patients were treated with HBO2: three patients were on continuous ambulatory peritoneal dialysis (CAPD) and two were on chronic haemodialysis therapy. None of the patients had uncontrolled hyperparathyroidism and none underwent parathyroidectomy. The patients each received 25-35 treatments of HBO2 at 2.5 atmospheres for 90 min per treatment. Two of these patients had complete resolution of extensive necrotic skin ulcers. with no adverse effects of HBO2 therapy. Both had improvement in wound area transcutaneous oxygen pressure (PtcO2) with administration of 100% oxygen when measurements were taken at normobaric and hyperbaric pressures. In the other three patients receiving HBO2, the skin lesions did not resolve. PteO2 was measured in two of these patients. neither of whom showed improvement with 100% oxygen administered at normobaric pressure. Conclusions. The data support a role for HBO2 in the treatment of some patients with calciphylaxis, particularly as in the absence of uncontrolled secondary hyperparathyroidism there are few therapeutic options.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:20:10