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Titolo:
Infection of dendritic cells by murine cytomegalovirus induces functional paralysis
Autore:
Andrews, DM; Andoniou, CE; Granucci, F; Ricciardi-Castagnoli, P; Degli-Esposti, MA;
Indirizzi:
Univ Western Australia, Dept Microbiol, QEII Med Ctr, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy Univ Milano Bicocca Milan Italy Dept Biotechnol & Biosci, Milan, Italy
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 11, volume: 2, anno: 2001,
pagine: 1077 - 1084
SICI:
1529-2908(200111)2:11<1077:IODCBM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; CLASS-II EXPRESSION; T-CELLS; INTERLEUKIN-2 PRODUCTION; ANTIGEN PRESENTATION; VIRUS INFECTION; CD8 EXPRESSION; MOUSE THYMUS; IN-VIVO; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Degli-Esposti, MA Univ Western Australia, Dept Microbiol, QEII Med Ctr, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 ralia
Citazione:
D.M. Andrews et al., "Infection of dendritic cells by murine cytomegalovirus induces functional paralysis", NAT IMMUNOL, 2(11), 2001, pp. 1077-1084

Abstract

Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanismsthat control CMV-induced immunosuppression. We hypothesized that dendriticcells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interferencewith DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:09:27