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Titolo:
Memory CD8(+)T cells in heterologous antiviral immunity and immunopathology in the lung
Autore:
Chen, HD; Fraire, AE; Joris, I; Brehm, MA; Welsh, RM; Selin, LK;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 Pathol, Worcester, MA 01655 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 11, volume: 2, anno: 2001,
pagine: 1067 - 1076
SICI:
1529-2908(200111)2:11<1067:MCCIHA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTIC CHORIOMENINGITIS VIRUS; CD8 T-CELLS; BYSTANDER ACTIVATION; VACCINIA VIRUS; IN-VIVO; DIRECT VISUALIZATION; VIRAL-INFECTION; ANTIGEN; RESPONSES; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Selin, LK Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 rcester, MA 01655 USA
Citazione:
H.D. Chen et al., "Memory CD8(+)T cells in heterologous antiviral immunity and immunopathology in the lung", NAT IMMUNOL, 2(11), 2001, pp. 1067-1076

Abstract

A potent role for memory CD8(+) T cells in heterologous immunity was shownwith a respiratory mucosal model of viral infection. Memory CD8(+) T cellsgenerated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.

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Documento generato il 25/01/20 alle ore 03:18:37