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Titolo:
IL-4 instructs T(H)1 responses and resistance to Leishmania major in susceptible BALB/c mice
Autore:
Biedermann, T; Zimmermann, S; Himmelrich, H; Gumy, A; Egeter, A; Sakrauski, AK; Seegmuller, I; Voigt, H; Launois, P; Levine, AD; Wagner, H; Heeg, K; Louis, JA; Rocken, M;
Indirizzi:
Univ Lausanne, Inst Biochem, WHO Immunol Res & Training Ctr, Lausanne, Switzerland Univ Lausanne Lausanne Switzerland Training Ctr, Lausanne, Switzerland Univ Munich, Dept Dermatol & Allergol, D-80337 Munich, Germany Univ Munich Munich Germany D-80337 l & Allergol, D-80337 Munich, Germany Tech Univ Munich, Dept Microbiol, D-8000 Munich, Germany Tech Univ MunichMunich Germany D-8000 Microbiol, D-8000 Munich, Germany Univ Marburg, Dept Microbiol, Marburg, Germany Univ Marburg Marburg Germany Marburg, Dept Microbiol, Marburg, Germany Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 11, volume: 2, anno: 2001,
pagine: 1054 - 1060
SICI:
1529-2908(200111)2:11<1054:IITRAR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; INFLAMMATORY AUTOIMMUNE-DISEASE; DENDRITIC CELLS; HELPER CELL; INTERLEUKIN-4-DEFICIENT MICE; MURINE LEISHMANIASIS; MOUSE INTERLEUKIN-4; IMMUNE DEVIATION; INNATE IMMUNITY; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Louis, JA Univ Lausanne, Inst Biochem, WHO Immunol Res & Training Ctr, Lausanne, Switzerland Univ Lausanne Lausanne Switzerland Ctr, Lausanne, Switzerland
Citazione:
T. Biedermann et al., "IL-4 instructs T(H)1 responses and resistance to Leishmania major in susceptible BALB/c mice", NAT IMMUNOL, 2(11), 2001, pp. 1054-1060

Abstract

Immunity to infection with intracellular pathogens is regulated by interleukin 12 (IL-12), which mediates protective T helper type I (T(H)1) responses, or IL-4, which induces T(H)2 cells and susceptibility. Paradoxically, weshow here that when present during the initial activation of dendritic cells (DCs) by infectious agents, IL-4 instructed DCs to produce IL-12 and promote T(H)1 development. This T(H)1 response established resistance to Leishmania major in susceptible BALB/c mice. When present later, during the period of T cell priming, IL-4 induced T(H)2 differentiation and progressive leishmaniasis in resistant mice. Because immune responses developed via the consecutive activation of DCs and then T cells, the contrasting effects of IL-4 on DC development and T cell differentiation led to immune responses that had opposing functional phenotypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:06:19