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Titolo:
A defect in central tolerance in NOD mice
Autore:
Kishimoto, H; Sprent, J;
Indirizzi:
Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA Scripps Res Inst La Jolla CA USA 92037 pt Immunol, La Jolla, CA 92037 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 11, volume: 2, anno: 2001,
pagine: 1025 - 1031
SICI:
1529-2908(200111)2:11<1025:ADICTI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONOBESE DIABETIC MICE; T-CELL REPERTOIRE; NEGATIVE SELECTION; CD4(+)CD8(+) THYMOCYTES; IN-VIVO; APOPTOSIS; DEATH; ACTIVATION; THYMUS; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Sprent, J Scripps Res Inst, Dept Immunol, IMM4,10550 N Torrey Pines Rd, LaJolla, CA92037 USA Scripps Res Inst IMM4,10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
H. Kishimoto e J. Sprent, "A defect in central tolerance in NOD mice", NAT IMMUNOL, 2(11), 2001, pp. 1025-1031

Abstract

The predisposition of nonobese diabetic (NOD) mice to develop autoimmune disease is usually attributed to defects in peripheral tolerance mechanisms. Here, evidence is presented that NOD mice display a defect in central tolerance (negative selection) of thymocytes. Impaired central tolerance in NODmice was most prominent in a population of semi-mature thymocytes found inthe medulla. The defect was apparent in vivo as well as in vitro, was independent of IA beta (g7) expression and affected both Fas-dependent and Fas-independent pathways of apoptosis; for Fas-dependent apoptosis, the defective tolerance of NOD thymocytes correlated with the strong T cell receptor-mediated up-regulation of caspase 8-homologous FLICE (Fas-associated death-domain-like interleukin I beta -converting enzyme)-inhibitory protein. In light of these findings, disease onset in NOD mice may reflect defects in central as well as peripheral tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:15:18