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Titolo:
Effects of a high-fat diet on postabsorptive and postprandial testosteroneresponses to a fat-rich meal
Autore:
Volek, JS; Gomez, AL; Love, DM; Avery, NG; Sharman, MJ; Kraemer, WJ;
Indirizzi:
Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA Ball State Univ Muncie IN USA 47306 Performance Lab, Muncie, IN 47306 USA
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 11, volume: 50, anno: 2001,
pagine: 1351 - 1355
SICI:
0026-0495(200111)50:11<1351:EOAHDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-CARBOHYDRATE DIET; MOUSE LEYDIG-CELLS; RESISTANCE EXERCISE; HORMONAL RESPONSES; BINDING GLOBULIN; KETOGENIC DIET; SEX-HORMONES; MEN; PLASMA; INSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Volek, JS Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA Ball State Univ Muncie IN USA 47306 e Lab, Muncie, IN 47306 USA
Citazione:
J.S. Volek et al., "Effects of a high-fat diet on postabsorptive and postprandial testosteroneresponses to a fat-rich meal", METABOLISM, 50(11), 2001, pp. 1351-1355

Abstract

Postprandial testosterone concentrations have been shown to significantly decrease after a fat-rich meal, which may be due to inhibition of testosterone production by chylomicrons. We examined the effects of a high-fat diet known to reduce postprandial chylomicrons on the testosterone response to afat-rich meal. Total testosterone (TT), free testosterone (FT), cortisol, and insulin responses to a high-fat test meal containing 5.44 MJ (1,300 kcal, 11% carbohydrate, 3% protein, 86% fat) were determined before (week 0) and after (week 8) an 8-week high-fat diet (64% fat) in 11 healthy men. The high-fat diet resulted in significant reductions in postabsorptive and postprandial serum triacylglycerols (55% and 50%, respectively). There were no significant changes in postabsorptive serum TT, FT, and cortisol, but insulin concentrations were significantly (P less than or equal to .05) lower atweek 8 (-28%). There was a significant reduction 1 hour after the fat-richmeal for TT (-22%) and FT (-23%), which remained significantly below baseline for 8 hours. Postprandial TT and FT responses were not significantly different after the 8-week high-fat diet. Postprandial serum cortisol concentrations were significantly reduced 1 hour after the meal. There were no significant differences before and after the high-fat diet. Insulin was significantly increased at the 0-, 1-, and 2-hour postprandial time points beforeand after the high-fat diet. Compared with week 0, insulin concentrations were significantly lower prior to and immediately after the fat-rich meal at week 8. These data indicate a fat-rich meal results in a prolonged reduction in TT and FT concentrations that is not altered by lowering postprandial chylomicrons. Alternative mechanisms (eg, higher uptake at the receptor level of cells) other than chylomicron-induced or insulin-induced inhibitionof steroidogenesis are likely responsible for the reduction in TT and FT after a fat-rich meal. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 20:21:15