Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviraltherapy
Autore:
Look, MP; Riezler, R; Berthold, HK; Stabler, SP; Schliefer, K; Allen, RH; Sauerbruch, T; Rockstroh, JK;
Indirizzi:
Univ Bonn, Dept Internal Med 1, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 ept Internal Med 1, D-53105 Bonn, Germany Severi Med, Munster, Germany Severi Med Munster GermanySeveri Med, Munster, Germany Univ Colorado, Dept Internal Med, Denver, CO 80202 USA Univ Colorado Denver CO USA 80202 Dept Internal Med, Denver, CO 80202 USA
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 11, volume: 50, anno: 2001,
pagine: 1275 - 1281
SICI:
0026-0495(200111)50:11<1275:DOENAN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HIV-SEROPOSITIVE INDIVIDUALS; SERUM CYSTATHIONINE LEVELS; PLACEBO-CONTROLLED TRIAL; S-ADENOSYLMETHIONINE; PROTEASE INHIBITORS; NUTRITIONAL-STATUS; FOLATE-DEFICIENCY; LIVER-CIRRHOSIS; DOUBLE-BLIND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Look, MP Univ Bonn, Dept Internal Med 1, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 onn, Germany
Citazione:
M.P. Look et al., "Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviraltherapy", METABOLISM, 50(11), 2001, pp. 1275-1281

Abstract

This study investigates fasting serum levels of methionine and related metabolites, vitamin B-6, and folate during highly active antiretroviral therapy in therapy-naive human immunodeficiency virus (HIV)-1-infected outpatients. The research design consisted of before and during therapy measurementswith a median treatment period of 100 days (range, 50 to 188) in frozen samples. The subjects included 17 consecutive HIV-1-infected outpatients (15 men and 2 women; 25 to 65-years-old). Controls were 42 healthy individuals (28 men and 14 women; 24- to 82-years-old) without serologic evidence of HIV and/or hepatitis C infection and normal clinical chemistry. Subjects received treatment with the reverse transcriptase inhibitors, azidothymidine (AZT) or stavudine (D4T) plus lamivudine (3TC) and either the protease inhibitors, indinavir (IND), nelfinavir (NELF), ritonavir (RITV), or saquinavir (SAQ) at the standard dosage. Serum concentrations of methionine, total homocysteine (tHcy), cystathionine (CYSTA), N,N-dimethylglycine (DMG), N-methylglycine (MG), methylmalonic acid (MMA), and total cysteine, as well as vitamin B-6, folate, and soluble tumor necrosis factor receptor p75 were taken at baseline and during highly active antiretroviral therapy. Baseline, serum tHcy, MMA, CYSTA, vitamin B-6 concentrations were not significantly different from healthy controls. There was, however, a trend towards lower folate serum concentrations at baseline in HIV-infected patients as compared with healthy controls (P = .06). There were no significant correlations between tHcy and vitamin B-6, folate, or MMA. Elevated baseline levels of DMG andMG decreased significantly during antiretroviral therapy (P = .0019 and .04, respectively), whereas no significant changes in serum concentrations ofCYSTA, MMA, or methionine were detected. tHcy increased in 12 of 17 patients (P = .09). HIV-infected patients displayed significant alterations (elevated DMG and MG serum concentrations) in metabolite levels of the betaine pathway in methionine metabolism, which might be positively influenced by newly initiated antiretroviral combination therapy. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:14:43