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Titolo:
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure
Autore:
Chatauret, N; Rose, C; Therrien, G; Butterworth, RF;
Indirizzi:
Univ Montreal, CHUM, Hop St Luc, Neurosci Res Unit, Montreal, PQ H2X 3J4, Canada Univ Montreal Montreal PQ Canada H2X 3J4 it, Montreal, PQ H2X 3J4, Canada
Titolo Testata:
METABOLIC BRAIN DISEASE
fascicolo: 1-2, volume: 16, anno: 2001,
pagine: 95 - 102
SICI:
0885-7490(200106)16:1-2<95:MHPCEA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID LACTATE; ACUTE AMMONIA INTOXICATION; BRAIN EDEMA; AMINO-ACIDS; HEPATIC-ENCEPHALOPATHY; RAT-BRAIN; METABOLISM; PLASMA;
Keywords:
hypothermia; acute liver failures; lactated; brain edema; hepatic encephalopathy; brain energy metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Butterworth, RF Univ Montreal, CHUM, Hop St Luc, Neurosci Res Unit, 1058 St Denis St, Montreal, PQ H2X 3J4, Canada Univ Montreal 1058 St Denis St Montreal PQ Canada H2X 3J4
Citazione:
N. Chatauret et al., "Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure", METAB BRAIN, 16(1-2), 2001, pp. 95-102

Abstract

Evidence from both clinical and experimental studies demonstrates that mild hypothermia prevents encephalopathy and brain edema in acute liver failure (ALF). As part of a series of studies to elucidate the mechanism(s) involved in this protective effect, groups of rats with ALF resulting from hepatic devascularization were maintained at either 37 degreesC (normothermic) or 35 degreesC (hypothermic), and neurological status was monitored in relation to cerebrospinal fluid (CSF) concentrations of ammonia and lactate. CSFwas removed via implanted cisterna magna catheters. Mild hypothermia resulted in a delay in onset of encephalopathy and prevention of brain edema; CSF concentrations of ammonia and lactate were concomitantly decreased. Bloodammonia concentrations, on the other hand, were not affected by hypothermia in ALF rats. These findings suggest that brain edema and encephalopathy in ALF are the consequence of ammonia-induced impairment of brain energy metabolism and open the way for magnetic resonance spectroscopic monitoring ofcerebral function in ALF. Mild hypothermia could be beneficial in the prevention of severe encephalopathy and brain edema in patients with ALF awaiting liver transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:35:17