Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cloning and developmental expression of zebrafish GTP cyclohydrolase I
Autore:
Pelletier, I; Bally-Cuif, L; Ziegler, I;
Indirizzi:
GSF, Res Ctr Environm & Hlth, Inst Clin Mol Biol & Tumor Genet, Munich, Germany GSF Munich Germany h, Inst Clin Mol Biol & Tumor Genet, Munich, Germany Tech Univ Munich, Jr Res Grp, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 r Res Grp, D-8000 Munich, Germany
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1, volume: 109, anno: 2001,
pagine: 99 - 103
SICI:
0925-4773(200111)109:1<99:CADEOZ>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL CREST; DANIO-RERIO; TETRAHYDROBIOPTERIN; BIOSYNTHESIS; EMBRYOS;
Keywords:
GTP cyclohydrolase I; pteridine; zebrafish; Danio rerio; pigment cells; xanthophore; melanophore; neural crest-derived cells; xanthine oxidase; catecholaminergic neurons; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Pelletier, I Univ Munich, Inst Anat, Biedersteinerstr 29, D-80802 Munich, Germany Univ Munich Biedersteinerstr 29 Munich Germany D-80802 rmany
Citazione:
I. Pelletier et al., "Cloning and developmental expression of zebrafish GTP cyclohydrolase I", MECH DEVEL, 109(1), 2001, pp. 99-103

Abstract

GTP cyclohydrolase I (GCH) catalyses the conversion of GTP to dihydroneopterin triphosphate, initiating the pteridine pathway. The final product tetrahydrobiopterin (H(4)biopterin) is the cofactor for neurotransmitter synthesis and for tyrosine supply during melanogenesis. Sepiapterin accumulates as a pigment. We cloned the zebrafish gch cDNA, which encodes a protein highly homologous to other vertebrate sequences and characterised the recombinant enzyme. By in situ hybridisation, we found that gch is expressed in boththe melanophore and xanthophore lineages during early development. gch-expression almost disappears after 3 days post-fertilisation (dpf), despite further sepiapterin synthesis. gch-transcripts are also located in catecholaminergic neurons, within the central nervous system and in the arch-associated neurons. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:34:14