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Titolo:
Effect of prolactin on the antigen presenting function of monocyte-deriveddendritic cells
Autore:
Matera, L; Mori, M; Galetto, A;
Indirizzi:
Univ Turin, Dept Internal Med, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 , Dept Internal Med, I-10126 Turin, Italy Univ Turin, Dept Oncol, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 v Turin, Dept Oncol, I-10126 Turin, Italy
Titolo Testata:
LUPUS
fascicolo: 10, volume: 10, anno: 2001,
pagine: 728 - 734
SICI:
0961-2033(2001)10:10<728:EOPOTA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; SERUM-FREE CONDITIONS; IMMUNE-SYSTEM; BONE-MARROW; IN-VITRO; BLOOD MONOCYTES; ERYTHROID PROGENITORS; GROWTH-HORMONE; KILLER-CELLS;
Keywords:
dendritic cells; monocytes; prolactin; interferon-gamma-autoimmunity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Matera, L Univ Turin, Dept Internal Med, Corso AM Dogliotti 14, I-10126 Turin, Italy Univ Turin Corso AM Dogliotti 14 Turin Italy I-10126 rin, Italy
Citazione:
L. Matera et al., "Effect of prolactin on the antigen presenting function of monocyte-deriveddendritic cells", LUPUS, 10(10), 2001, pp. 728-734

Abstract

Monocyte derived macrophages (M phi) and dendritic cells (DC) play critical roles at the interface between innate and adaptive immunity. Both types of cells can effectively phagocytose exogenous antigens, whereas only DC canprocess and present them efficiently to antigen-specific T lymphocytes. The hormone PRL is also produced by immune cells and is regarded as a key component of the neuroendocrine-immune loop and a local regulator of lymphocyte response. Its main feature is cooperation with cytokines and hemopoietins. Triggering of monocyte PRL receptors with physiological-to-supraphysiological concentrations of PRL up-regulates the GM-CSF receptors, resulting in synergistic PRL-GM-CSF induced maturation of immature (i)DC. Further incubation induces increased antigen-presenting activity at the highest PRL concentrations studied (200 ng/ml). IFN-gamma release by allogeneic lymphocytes is dependent on T cell-triggered IL-12 release by PRL-preincubated iDC. This, in turn, may be secondary to increased DC expression of CD40 or IFN-gamma. The permissive action of high PRL concentrations in the antigen presenting process may be of significance in initiation of the response against major histocompatibility complex (MHC)-presented self-antigens and may explainthe association of hyperprolactinemia with autoimmune diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:21:55