Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
S-100b and neuron-specific enolase in patients with fulminant hepatic failure
Autore:
Strauss, GI; Christiansen, M; Moller, K; Clemmesen, JO; Larsen, FS; Knudsen, GM;
Indirizzi:
Univ Copenhagen, Rigshosp, Dept Hepatol A2121, DK-2100 Copenhagen, DenmarkUniv Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark Univ Copenhagen, Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark Univ Copenhagen, Rigshosp, Dept Neurol, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark StatensSerum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 11, volume: 7, anno: 2001,
pagine: 964 - 970
SICI:
1527-6465(200111)7:11<964:SANEIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEAD-INJURY; ACUTE LIVER-FAILURE; CORONARY-ARTERY BYPASS; CEREBROSPINAL-FLUID; CEREBRAL EDEMA; OUTCOME PREDICTION; CARDIAC-ARREST; BLOOD-FLOW; SERUM; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Strauss, GI Univ Copenhagen, Rigshosp, Dept Hepatol A2121, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Univ Copenhagen Blegdamsvej 9 Copenhagen Denmark DK-2100 mark
Citazione:
G.I. Strauss et al., "S-100b and neuron-specific enolase in patients with fulminant hepatic failure", LIVER TRANS, 7(11), 2001, pp. 964-970

Abstract

Patients with fulminant hepatic failure (FHF) frequently develop cerebral edema and intracranial hypertension. The aim of this study was to evaluate circulating S-100b and neuron-specific enolase (NSE) levels as markers of neurological outcome in patients with ME In a subgroup of patients, the cerebral flux of S-100b and NSE was measured. We included 35 patients with FHF,6 patients with acute on chronic liver disease (AOCLD), 13 patients with cirrhosis of the liver without hepatic encephalopathy, and 8 healthy subjects. Blood samples were obtained from catheters placed in the radial artery and internal jugular bulb. The net cerebral flux of S-100b and NSE was measured, and the effect of short-term hyperventilation, as well as the effect of high-volume plasmapheresis, on circulating levels of these two biomarkerswas determined. Blood levels of S-100b were greater in patients with FHF and AOCLD than patients with cirrhosis and healthy subjects (median, 0.39 mug/L; range, 0.02 to 10.31 mug/L; and 1.11 mug/L; range, 0.19 to 4.84 mug/L v 0.05 mug/L; range, 0.02 to 0.27 mug/L; and 0.09 mug/L, range, 0.02 to 0.15 mug/L, respectively; P < .05, ANOVA). Among patients with FHF, blood levels of NSE tended to be greater in patients who subsequently developed cerebral herniation than in survivors (median, 10.5 mug/L; range, 5.2 to 15.9 mug/L v 5.1 mug/L; range, 2.8 to 12 mug/L; P = .05). There was no net cerebral flux of S-100b or NSE. Short-term hyperventilation had no effect on any of these measures, whereas high-volume plasmapheresis reduced circulating S-100b levels from 0.45 mug/L (range, 0.19 to 10.31 mug/L) to 0.42 mug/L (range, 0.11 to 6.35 mug/L; P = .01). In conclusion, blood levels of S-100b were elevated in almost all patients with FHF and AOCLD, but were unrelated tosurvival. Conversely, NSE showed a clear tendency toward greater circulating levels in patients with FHF who subsequently developed cerebral herniation than in survivors. This finding encourages farther evaluation of NSE as a marker of neurological outcome in FHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:30:13