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Titolo:
Neurotoxicity of immunosuppressive drugs
Autore:
Wijdicks, EFM;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 urol, Rochester, MN 55905 USA
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 11, volume: 7, anno: 2001,
pagine: 937 - 942
SICI:
1527-6465(200111)7:11<937:NOID>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOSPORINE-ASSOCIATED HEADACHE; LIVER-TRANSPLANT RECIPIENTS; BLOOD-BRAIN-BARRIER; A NEUROTOXICITY; NERVOUS-SYSTEM; LEUKOENCEPHALOPATHY; ENCEPHALOPATHY; TOXICITY; MUTISM; OKT3;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Wijdicks, EFM Mayo Clin & Mayo Fdn, Dept Neurol, W8A,200 1st St, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn W8A,200 1st St Rochester MN USA 55905 A
Citazione:
E.F.M. Wijdicks, "Neurotoxicity of immunosuppressive drugs", LIVER TRANS, 7(11), 2001, pp. 937-942

Abstract

The clinical profile of neurotoxicity caused by immunosuppression has changed. When toxic levels are reached, both cyclosporine and tacrolimus may produce a clinical spectrum that varies from tremor and acute confusional state to status epilepticus; and major speech or language abnormalities. Coma has become an unusual manifestation. Magnetic resonance imaging has been better defined, and abnormalities may be more widespread than those in the posterior lobes. These white matter lesions are caused by vasogenic edema, but may lead to apoptosis an cytotoxic edema if exposure is prolonged. Recentevidence suggests inhibition of a drug-efflux: pump and dysfunction of theblood-brain barrier by enhanced nitric oxide production.

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Documento generato il 26/01/20 alle ore 10:10:54