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Titolo:
Effects of repeated doses of MDMA ("ecstasy") on cell-mediated immune response in humans
Autore:
Pacifici, R; Zuccaro, P; Farre, M; Pichini, S; Di Carlo, S; Roset, PN; Ortuno, J; Pujadas, M; Bacosi, A; Menoyo, E; Segura, J; de la Torre, R;
Indirizzi:
Univ Autonoma Barcelona, Inst Municipal Invest Med, Dept Pharmacol, E-08003 Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain E-08003 E-08003 Barcelona, Spain Univ Pompeu Fabra, Barcelona, Spain Univ Pompeu Fabra Barcelona SpainUniv Pompeu Fabra, Barcelona, Spain Ist Super Sanita, Dept Clin Biochem, Rome, Italy Ist Super Sanita Rome Italy uper Sanita, Dept Clin Biochem, Rome, Italy
Titolo Testata:
LIFE SCIENCES
fascicolo: 24, volume: 69, anno: 2001,
pagine: 2931 - 2941
SICI:
0024-3205(20011102)69:24<2931:EORDOM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; MECHANISMS; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; NEUROENDOCRINE; EXERCISE; COCAINE; STRESS;
Keywords:
MDMA; humans; immunity; repeated administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: de la Torre, R Univ Autonoma Barcelona, Inst Municipal Invest Med, Dept Pharmacol, DoctorAiguader 80, E-08003 Barcelona, Spain Univ Autonoma Barcelona Doctor Aiguader 80 Barcelona Spain E-08003
Citazione:
R. Pacifici et al., "Effects of repeated doses of MDMA ("ecstasy") on cell-mediated immune response in humans", LIFE SCI, 69(24), 2001, pp. 2931-2941

Abstract

Cell-mediated immune response after the administration of two repeated doses of 100 mg 3,4-methylenedioxymethamphetamine (MDMA) at 4-hour and 24-hourintervals was evaluated in two randomised, double-blind and cross-over clinical trials conducted in healthy male MDMA consumers. MDMA produced a time-dependent decrease in the CD4/CD8 T-cell ratio due to a decrease in the number of CD4 T-helper cells, a decrease in the functional responsiveness of lymphocytes to mitogenic stimulation, and a simultaneous increase in natural killer cells. In case of two 100 mg MDMA doses given 4 hour apart, immunealterations produced by the first dose were strengthened by the second one. At 24 hours after treatment, statistically significant residual effects were observed for all the altered immune parameters after the administrationof two MDMA doses if compared to single dose and placebo. In the second clinical trial, the second 100 mg MDMA dose given 24 hours after the first dose produced immunological changes significantly greater than those induced by the initial drug administration and which seemed to show a delayed onset. Significant residual effects were observed for all the immune parameters as late as 48 hours after the second dose. These results show that repeatedadministration of MDMA with both a short and a long time interval between doses extends the critical period following MDMA administration, already observed after a single dose, in which immunocompetence is severely compromised. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:07:15