Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits
Autore:
Jeon, SM; Bok, SH; Jang, MK; Lee, MK; Nam, KT; Park, YB; Rhee, SJ; Choi, MS;
Indirizzi:
Kyungpook Natl Univ, Dept Food Sci & Nutr, Puk Ku, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea KIST, Korea Inst Biosci & Biotechnol, Taejon 305333, South Korea KIST Taejon South Korea 305333 & Biotechnol, Taejon 305333, South Korea Kyungpook Natl Univ, Taegu 702701, South Korea Kyungpook Natl Univ TaeguSouth Korea 702701 , Taegu 702701, South Korea Catholic Univ Taegu, Dept Food Sci & Nutr, Kyongsan, South Korea Catholic Univ Taegu Kyongsan South Korea & Nutr, Kyongsan, South Korea
Titolo Testata:
LIFE SCIENCES
fascicolo: 24, volume: 69, anno: 2001,
pagine: 2855 - 2866
SICI:
0024-3205(20011102)69:24<2855:AAONAL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LIVER-MICROSOMES; OXYGEN-FREE-RADICALS; LIPID-PEROXIDATION; HEPATIC CHOLESTEROL; RED-CELLS; FLAVONOIDS; PLASMA; RATS; ACTIVATION; OXIDATION;
Keywords:
high-cholesterol diet; naringin; lovastatin; antioxidant enzymes; lipid peroxide; gene expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Choi, MS Kyungpook Natl Univ, Dept Food Sci & Nutr, Puk Ku, 1370 Sankyuk Dong, Taegu 702701, South Korea Kyungpook Natl Univ 1370 Sankyuk Dong TaeguSouth Korea 702701 a
Citazione:
S.M. Jeon et al., "Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits", LIFE SCI, 69(24), 2001, pp. 2855-2866

Abstract

The consumption of a cholesterol-enriched diet increases the degree of lipid peroxidation, which is one of the early processes of atherosclerosis. The aim of this trial was to determine the antioxidative effects of the citrus bioflavonoid, naringin, a potent cholesterol-lowering agent, compared to the cholesterol-lowering drug, lovastatin, in rabbits fed a high cholesterol diet. Male rabbits were served a high-cholesterol (0.5%, w/w) diet or high-cholesterol diet supplemented with either naringin (0.5% cholesterol, 0.05% naringin, w/w) or lovastatin (0.5% cholesterol, 0.03% lovastatin, w/w) for 8 weeks to determine the plasma and hepatic lipid peroxide, plasma vitamin A and E levels, and hepatic hydrogen peroxide levels, along with the hepatic antioxidant enzyme activities and gene expressions. Only the lovastatin group showed significantly lower plasma and hepatic lipid peroxide levelscompared to the control group. The naringin supplementation significantly increased the activities of both hepatic SOD and catalase by 33% and 20%, respectively, whereas the lovastatin supplementation only increased the catalase activity by 23% compared to control group. There was no difference in the GSH-Px. activities between the various groups. Content of H2O2 in hepatic mitochondria was significantly lower in groups supplemented with lovastatin and naringin than in control group. However, there was no difference incytosolic H2O2 content in liver between groups. The concentration of plasma vitamin E was significantly increased by the naringin supplementation. When comparing the antioxidant enzyme gene expression, the mRNA expression ofSOD, catalase and GSH-Px was significantly up-regulated in the naringin-supplemented group. Accordingly, these results would appear to indicate that naringin, a citrus bioflavonoid, plays an important role in regulating antioxidative capacities by increasing the SOD and catalase activities, up-regulating the gene expressions of SOD, catalase, and GSH-Px, and protecting the plasma vitamin E. In contrast, lovastatin exhibited an inhibitory effect on the plasma and hepatic lipid peroxidation and increased the hepatic catalase activity in high-cholesterol fed rabbits. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:05:48