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Titolo:
Pyrazolopyrimidines
Autore:
George, CFP;
Indirizzi:
Univ Western Ontario, London Hlth Sci Ctr, London, ON N6A 4G5, Canada UnivWestern Ontario London ON Canada N6A 4G5 London, ON N6A 4G5, Canada
Titolo Testata:
LANCET
fascicolo: 9293, volume: 358, anno: 2001,
pagine: 1623 - 1626
SICI:
0140-6736(20011110)358:9293<1623:P>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP LATENCY; ZALEPLON; ZOLPIDEM; INSOMNIA; PSYCHOMOTOR; MEMORY; PERFORMANCE; RECEPTORS; TRIAZOLAM; PLACEBO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: George, CFP Univ Western Ontario, London Hlth Sci Ctr, Victoria Campus,375South St, London, ON N6A 4G5, Canada Univ Western Ontario Victoria Campus,375 South St London ON Canada N6A 4G5
Citazione:
C.F.P. George, "Pyrazolopyrimidines", LANCET, 358(9293), 2001, pp. 1623-1626

Abstract

Pharmacological therapy has an important role in the management of insomnia. Although older drugs are highly effective for initiating and maintainingsleep, tolerance and withdrawal effects as well as impairment of daytime performance are commonly troublesome and limit their use. Aided by increasedknowledge of gamma-aminobutyric acid (GABA) and its receptors, new hypnotic sedatives have been developed that are Increasingly selective for the various subunits of the GABA receptor. This development has produced newer agents with very favourable hypnotic profiles and side-effect profiles that provide better treatment options for medical practitioners. The pyrazolopyrimidines, the latest in this area, seem to offer some advantages over other agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:25:33