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Titolo:
Therapeutic effect of hyaluronic acid on experimental osteroarthrosis of ovine temporomandibular joint
Autore:
Kim, CH; Lee, BJ; Yoon, J; Seo, KM; Park, JH; Lee, JW; Choi, ES; Hong, JJ; Lee, YS; Park, JH;
Indirizzi:
Seoul Natl Univ, Coll Vet Med, Dept Lab Anim Med, Kwonsun Gu, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 n Gu, Suwon 441744, South Korea Seoul Natl Univ, Coll Vet Med, Dept Vet Publ Hlth, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 Hlth, Suwon 441744, South Korea Seoul Natl Univ, Coll Vet Med, Dept Vet Radiol, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 diol, Suwon 441744, South Korea Kangweon Natl Univ, Coll Vet Med, Dept Anim Surg, Chunchon, South Korea Kangweon Natl Univ Chunchon South Korea nim Surg, Chunchon, South Korea
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 10, volume: 63, anno: 2001,
pagine: 1083 - 1089
SICI:
0916-7250(200110)63:10<1083:TEOHAO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAARTICULAR HYALURONAN; SODIUM HYALURONATE; MOLECULAR-WEIGHT; OSTEOARTHRITIS; CARTILAGE; MODEL; SHEEP; KNEE;
Keywords:
hyaluronic acid; osteoarthrosis; ovine; temporomandibular joint;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Park, JH Seoul Natl Univ, Coll Vet Med, Dept Lab Anim Med, Kwonsun Gu, 103Seodun Dong, Suwon 441744, South Korea Seoul Natl Univ 103 Seodun Dong Suwon South Korea 441744 h Korea
Citazione:
C.H. Kim et al., "Therapeutic effect of hyaluronic acid on experimental osteroarthrosis of ovine temporomandibular joint", J VET MED S, 63(10), 2001, pp. 1083-1089

Abstract

A symptomatic relief by hyaluronic acid (HA, MW: 3.5 x 10(6)), which is synthesized by Streptococcus spp, was investigated in experimental ovine osteoarthrosis. Bilateral osteoarthrosis (OA) of the temporo-mandibular joints (TMJs) was induced by perforating discs and by scrapping subchondral condylar surface, HA was intra-articularly injected into the left joints of 6 sheep on 7, 10, 14, 17 and 21 days after the operation and physiological saline as the control was injected into the contralateral (right) joints on the same day. Three sheep were killed at I month post-operation (MPO) and the remaining three sheep were killed at 3 MPO. Various responses such as proliferation of fibrous tissue, denudation, erosion, osteophyte, formation, subcortical cyst formation and ankylosis were observed radiographically and histopathologically. The treatment of HA ameliorated the degenerative changes and lowered the osteoarthrotic score in the left joints at 1 MPO (9.96 vs 5.81) and 3 MPO (10.86 vs 5.29) compared to the right joints. These results indicate that a repeated intra-articular injection of HA inhibits the progression of OA in ovine TMJs by inducing the development of articular cartilage and by reducing the proliferation of fibrotic tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:48:18