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Titolo:
Tick-encoded serine proteinase inhibitors (Serpins); Potential target antigens for tick vaccine development
Autore:
Mulenga, A; Sugino, M; Nakajima, M; Sugimoto, C; Onuma, M;
Indirizzi:
Hokkaido Univ, Grad Sch Vet Med, Kita Ku, Sapporo, Hokkaido 0600818, JapanHokkaido Univ Sapporo Hokkaido Japan 0600818 oro, Hokkaido 0600818, Japan Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan Obihiro Univ Agr & Vet Med Obihiro Hokkaido Japan 0808555 0808555, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 10, volume: 63, anno: 2001,
pagine: 1063 - 1069
SICI:
0916-7250(200110)63:10<1063:TSPI(P>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR COAGULATION INHIBITOR; INTERLEUKIN-1-BETA CONVERTING-ENZYME; HORSESHOE-CRAB HEMOCYTES; FAS-MEDIATED APOPTOSIS; VIRUS SERPIN; BOOPHILUS-MICROPLUS; SALIVARY-GLANDS; PROTEASE ZYMOGEN; CDNA CLONING; ANTICOAGULANT ACTIVITIES;
Keywords:
ixodid tick; serpin; tick vaccine development;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Mulenga, A Hokkaido Univ, Grad Sch Vet Med, Kita Ku, Kita 18,Nishi 9, Sapporo, Hokkaido 0600818, Japan Hokkaido Univ Kita 18,Nishi 9 Sapporo HokkaidoJapan 0600818 an
Citazione:
A. Mulenga et al., "Tick-encoded serine proteinase inhibitors (Serpins); Potential target antigens for tick vaccine development", J VET MED S, 63(10), 2001, pp. 1063-1069

Abstract

Immunological protection of hosts against tick infestation is at present the most practically sustainable alternative tick control method to the current use of acaricides that is riddled with serious limitations. The currentfocus of tick vaccine research is the identification, cloning and in vitroproduction of recombinant tick vaccine candidate antigens. We have examined a selected number of reports on the roles of parasite-encoded members of the serine proteinase inhibitor (serpin) superfamily in modulation of mammalian anti-parasite defense and developed some food for thought commentarieson the possibility of targeting this class of proteins for anti-tick vaccine development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:43:14