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Titolo:
Reactive stroma in prostate cancer progression
Autore:
Tuxhorn, JA; Ayala, GE; Rowley, DR;
Indirizzi:
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pathol, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 6, volume: 166, anno: 2001,
pagine: 2472 - 2483
SICI:
0022-5347(200112)166:6<2472:RSIPCP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE CELLS; TUMOR-ASSOCIATED MACROPHAGES; FACTOR VEGF EXPRESSION; HUMAN-SKIN FIBROBLASTS; HUMAN BREAST-CANCER; FACTOR-BETA; EXTRACELLULAR-MATRIX; CONNECTIVE-TISSUE; IN-VIVO;
Keywords:
prostate; prostatic neoplasms; growth substances; granulation tissue; extracellular matrix;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Tuxhorn, JA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 l, Houston, TX 77030 USA
Citazione:
J.A. Tuxhorn et al., "Reactive stroma in prostate cancer progression", J UROL, 166(6), 2001, pp. 2472-2483

Abstract

Purpose: The development of an altered stromal microenvironment in response to carcinoma is a common feature of many tumors. We reviewed the literature describing characteristics of reactive stroma, how reactive stroma affects cancer progression and how carcinoma regulates reactive stroma. Moreover, we present a hypothesis of reactive stroma in prostate cancer and discusshow the biology of reactive stroma may be used in novel diagnostic and therapeutic approaches. Materials and Methods: An extensive literature search was performed to review reports of the general features of wound repair stroma, general stromalresponses to carcinoma, and stromal biology of normal and prostate cancer tissues. These studies were analyzed and a reactive stroma hypothesis in prostate cancer was developed. Results: Modifications to the stroma of breast, colon and prostate tumors parallel the generation of granulation tissue in wound repair. These changes include stromal cell phenotypic switching, extracellular matrix remodeling and angiogenesis induction. Therefore, it is predicted that a modified wound healing response induces the formation of reactive stroma in cancer to create a tumor promoting environment. Based on its role in wound repair andits over expression in prostate cancer, transforming growth factor-beta stands out as a potential regulator of reactive stroma. Conclusions: Reactive stroma in prostate cancer and granulation tissue in wound repair show similar biological responses and processes that are predicted to promote cancer progression. Further identification of specific functional and regulatory mechanisms in prostate cancer reactive stroma may aidin the use of reactive stroma for novel diagnostic and therapeutic approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 12:58:58