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Titolo:
External radiation of the parotid glands significantly reduces drooling inpatients with motor neurone disease with bulbar paresis
Autore:
Andersen, PM; Gronberg, H; Franzen, L; Funegard, U;
Indirizzi:
Umea Univ, Dept Clin Neurosci, Umea, Sweden Umea Univ Umea SwedenUmea Univ, Dept Clin Neurosci, Umea, Sweden Umea Univ, Dept Radiat Sci, Umea, Sweden Umea Univ Umea SwedenUmea Univ, Dept Radiat Sci, Umea, Sweden Umea Univ, Dept Oncol, Umea, Sweden Umea Univ Umea SwedenUmea Univ, Dept Oncol, Umea, Sweden Umea Univ, Dept Odontol, Umea, Sweden Umea Univ Umea SwedenUmea Univ, Dept Odontol, Umea, Sweden
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 191, anno: 2001,
pagine: 111 - 114
SICI:
0022-510X(20011015)191:1-2<111:EROTPG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; MANAGEMENT; SIALORRHEA; GLYCOPYRROLATE; POPULATION; CANCER;
Keywords:
ALS; motor neurone disease; drooling; quality of life; terminal care;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Andersen, PM Univ Umea Hosp, Dept Neurol, SE-90185 Umea, Sweden Univ Umea Hosp Umea Sweden SE-90185 , SE-90185 Umea, Sweden
Citazione:
P.M. Andersen et al., "External radiation of the parotid glands significantly reduces drooling inpatients with motor neurone disease with bulbar paresis", J NEUR SCI, 191(1-2), 2001, pp. 111-114

Abstract

The parotid glands and part of the submandibular glands were irradiated in18 amyotrophic lateral sclerosis patients with very advanced disease and severe drooling problems. In a prospective study, a single dosage of 7.0-7.5Gy was administered bilateral to the larger part of the parotid glands andthe posterior parts of the submandibular glands. Salivary secretion rate was assayed before and after radiotherapy. Sixteen out of eighteen patients reported satisfactory to good reduction in drooling lasting up to 4-6 months, 1/18 developed xerostomia and needed saliva substitutes, and 1/18 reported no effect. Caregivers reported positive effect in all patients. The procedure was well tolerated with few side effects. Low dosage external radiotherapy of the salivary glands is effective in reducing drooling satisfactorily in ALS patients, especially in well-hydrated patients. (C) 2001 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:38:06