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Titolo:
Facile synthesis of 6-cyano-9-substituted-9H-purines and their ring expansion to 8-(arylamino)-4-imino-3-methylpyrimidino[5,4-d]pyrimidines
Autore:
Al-Azmi, A; Booth, BL; Carpenter, RA; Carvalho, A; Marrelec, E; Pritchard, RG; Proenca, MFJRP;
Indirizzi:
Univ Manchester, Inst Sci & Technol, Dept Chem, Manchester M60 1QD, Lancs,England Univ Manchester Manchester Lancs England M60 1QD r M60 1QD, Lancs,England Univ Minho, Dept Chem, Braga, Portugal Univ Minho Braga PortugalUniv Minho, Dept Chem, Braga, Portugal
Titolo Testata:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
fascicolo: 20, , anno: 2001,
pagine: 2532 - 2537
SICI:
1472-7781(20011021):20<2532:FSO6AT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICONVULSANT AGENTS; 6-CARBAMOYL-1,2-DIHYDROPURINES; CYANIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Booth, BL Univ Manchester, Inst Sci & Technol, Dept Chem, POB 88, Manchester M60 1QD, Lancs, England Univ Manchester POB 88 Manchester Lancs England M60 1QD England
Citazione:
A. Al-Azmi et al., "Facile synthesis of 6-cyano-9-substituted-9H-purines and their ring expansion to 8-(arylamino)-4-imino-3-methylpyrimidino[5,4-d]pyrimidines", J CHEM S P1, (20), 2001, pp. 2532-2537

Abstract

6-Cyano-9-substituted-9H-purines were prepared in a high yielding, one-step process by refluxing triethyl orthoformate or triethyl orthopropionate with the corresponding (Z)-N-1-(aryl- or benzyl)-N-2-(2-amino-1-,2-dicyanovinyl)formamidines. Attempted reaction of these cyanopurines with aqueous methylamine-furnished 8-(arylamino)-4-imino-3-methylpyrimidino[5,4-d]pyrimidines, by attack at the imidazole ring rather than addition to the 6-cyano group. All compounds have been fully characterised by spectroscopic data and anX-ray crystal structure determination has been carried out on the 8-(4-methoxyanilino)-4-imino-3-methylpyrimidino[5,4-d]pyrimidine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:05:02