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Titolo:
Enantioseparation of antiarrhythmic drugs propafenone and diprafenone, their metabolites and analogs by capillary electrophoresis
Autore:
Chankvetadze, B; Lomsadze, K; Blaschke, G;
Indirizzi:
Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany Univ MunsterMunster Germany D-48149 ceut Chem, D-48149 Munster, Germany Tbilisi State Univ, Sch Chem, Mol Recognit & Separat Sci Lab, GE-380028 Tbilisi, Rep of Georgia Tbilisi State Univ Tbilisi Rep of Georgia GE-380028lisi, Rep of Georgia
Titolo Testata:
JOURNAL OF SEPARATION SCIENCE
fascicolo: 9, volume: 24, anno: 2001,
pagine: 795 - 801
SICI:
1615-9314(200109)24:9<795:EOADPA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHIRAL RESOLVING AGENTS; PERFORMANCE LIQUID-CHROMATOGRAPHY; STATIONARY-PHASE; SOLVATING AGENT; 5-HYDROXYPROPAFENONE ENANTIOMERS; ENANTIOSELECTIVE DETERMINATION; GAMMA-CYCLODEXTRIN; MAJOR METABOLITES; CHINESE SUBJECTS; HUMAN PLASMA;
Keywords:
capillary electrophoresis; enantioseparations; chiral drugs; propafenone and metabolites; diprafenone and metabolites; N-ethylpropafenone; alprafenone; cyclodextrins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Blaschke, G Univ Munster, Inst Pharmaceut Chem, Hittorfstr 58-62, D-48149 Munster, Germany Univ Munster Hittorfstr 58-62 Munster Germany D-48149 Germany
Citazione:
B. Chankvetadze et al., "Enantioseparation of antiarrhythmic drugs propafenone and diprafenone, their metabolites and analogs by capillary electrophoresis", J SEP SCI, 24(9), 2001, pp. 795-801

Abstract

The enantioseparation of antiarrhythmic drugs propafenone (PF), diprafenone (DF), their metabolites and analogs was studied by capillary electrophoresis (CE). Several cyclodextrin-type chiral selectors, such as native alpha,beta, and gamma -cyclodextrin (CD), selectively and randomly substituted neutral and charged derivatives of P-CD were not suitable for the enantioseparation of PF. The acceptable simultaneous enantioseparation of PF and its major metabolites, 5-hydroxypropafenone (5-OH-PF) and N-despropylpropafenone (N-Des-PF), was achieved with a designed mixture of randomly substituted carboxymethyl-beta -CD (CM-beta -CD) and sulfated beta -CD (SU-beta -CD). The method was also developed for the simultaneous enantioseparation of DF and its major metabolites, 5-hydroxydiprafenone (5-OH-DF) and N-desalkyldiprafenone (N-Des-DF) as well as other chiral compounds with a similar structure, such as N-ethylpropafenone and alprafenone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:29:45