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Titolo:
A capillary zone electrophoretic method for the determination of nimesulide in pharmaceutical preparation and serum
Autore:
Dogrukol-Ak, D; Tuncel, M; Aboul-Enein, HY;
Indirizzi:
King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr Riyadh Saudi Arabia 11211 i Arabia Anadolu Univ, Fac Pharm, Dept Analyt Chem, TR-26470 Eskisehir, Turkey Anadolu Univ Eskisehir Turkey TR-26470 Chem, TR-26470 Eskisehir, Turkey
Titolo Testata:
JOURNAL OF SEPARATION SCIENCE
fascicolo: 9, volume: 24, anno: 2001,
pagine: 743 - 748
SICI:
1615-9314(200109)24:9<743:ACZEMF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN-PLASMA; HPLC DETERMINATION; HYDROXYNIMESULIDE;
Keywords:
nimesulide; capillary zone electrophoresis; pharmaceutical analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Aboul-Enein, HY King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Pharmaceut Anal Lab, MBC-03,POB 3354, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr MBC-03,POB 3354 Riyadh Saudi Arabia 11211
Citazione:
D. Dogrukol-Ak et al., "A capillary zone electrophoretic method for the determination of nimesulide in pharmaceutical preparation and serum", J SEP SCI, 24(9), 2001, pp. 743-748

Abstract

A simple capillary zone electrophoretic (CZE) method was developed to determine nimesulide in pharmaceutical tablet formulations and serum. Method development was conducted in a fused-silica capillary using a background electrolyte of 10 mM borate buffer containing 10% ethanol at pH 8.1, injecting for 1 s by vacuum injection, applying 30 kV. Salicylic acid was found to bea good internal standard (IS) and detection was performed at 200 nm. Nimesulide and IS appeared at average migration times (RSD%) of 7.2 (0.75%) and 10.4 (0.91%) min, respectively. The limit of detection (S/N= 3) and limit of quantitation (S/N= 10) were 2.2 x 10(-6) M and 6.7 x 10(-6) M, respectively. The method was applied to the tablets containing 100 mg nimesulide and the results were compared to those of UV-spectrophotometry. The recoveries of methods (as mean (mg) RSD%) were found to be 99.6 +/- 1.59 for CZE and 98.9 +/- 1.04 for UV spectrophotometry. The proposed method was also appliedfor the determination of nimesulide in serum by the standard addition technique. The proposed method is sensitive, precise, and easy to use for the determination of nimesulide in tablets and serum.

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Documento generato il 23/01/20 alle ore 12:15:18