Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin
Autore:
Fulia, F; Gitto, E; Cuzzocrea, S; Reiter, RJ; Dugo, L; Gitto, P; Barberi, S; Cordaro, S; Barberi, I;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 truct Biol, San Antonio, TX 78229 USA Univ Messina, Sch Med, Div Neonatal Care, I-98100 Messina, Italy Univ Messina Messina Italy I-98100 Neonatal Care, I-98100 Messina, Italy Univ Messina, Inst Pharmacol, I-98100 Messina, Italy Univ Messina Messina Italy I-98100 nst Pharmacol, I-98100 Messina, Italy
Titolo Testata:
JOURNAL OF PINEAL RESEARCH
fascicolo: 4, volume: 31, anno: 2001,
pagine: 343 - 349
SICI:
0742-3098(200111)31:4<343:ILOMAN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLULAR-ENERGY DEPLETION; NITRIC-OXIDE SYNTHASE; LIPID-PEROXIDATION; BACTERIAL LIPOPOLYSACCHARIDE; RESPIRATORY-CHAIN; COMPLEX-I; PEROXYNITRITE; RAT; INHIBITION; SYNTHETASE;
Keywords:
asphyxia; lipid peroxidation; melatonin; newborn; nitrite/nitrate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Reiter, RJ Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, Mail Code 7762,7703Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas Mail Code 7762,7703 Floyd Curl Dr San Antonio TX USA 78229
Citazione:
F. Fulia et al., "Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin", J PINEAL R, 31(4), 2001, pp. 343-349

Abstract

Free radicals have been implicated in the pathogenesis of neonatal asphyxia and its complications. This study measured a product of lipid peroxidation, malondialdehyde, and the nitrite/nitrate levels in the serum of 20 asphyxiated newborns before and after treatment with the antioxidant melatonin given within the first 6 hr of life, Ten asphyxiated newborns received a total of 80 mg of melatonin (8 doses of 10 mg each separated by 2-hr intervals) orally. One blood sample was collected before melatonin administration and two additional blood samples (at 12 and 24 hr) were collected after giving melatonin. A third group of healthy newborn children served as controls. Serum malondialdehyde and nitrite + nitrate concentrations in newborns withasphyxia before treatment were significantly higher than those in infants without asphyxia. In the asphyxiated newborns given melatonin, there were significant reductions in malondialdehyde and nitrite/nitrate levels at both12 and 24 hr. Three of the 10 asphyxiated children not given melatonin died within 72 hr after birth, none of the 10 asphyxiated newborns given melatonin died. The results indicate that the melatonin may be beneficial in thetreatment of newborn infants with asphyxia. The protective actions of melatonin in this study may relate to the antioxidant properties of the indole as well as to the ability of melatonin to increase the efficiency of mitochondrial electron transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:45:02