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Titolo:
The role of central 5-HT1A receptors in the control of B-fibre cardiac andbronchoconstrictor vagal preganglionic neurones in anaesthetized cats
Autore:
Wang, Y; Ramage, AG;
Indirizzi:
Univ Coll London, Dept Pharmacol, London NW3 2PF, England Univ Coll London London England NW3 2PF armacol, London NW3 2PF, England
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 3, volume: 536, anno: 2001,
pagine: 753 - 767
SICI:
0022-3751(20011101)536:3<753:TROC5R>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; BEZOLD-JARISCH REFLEX; ANESTHETIZED CATS; SEROTONERGIC PROJECTIONS; SEROTONIN-1 RECEPTORS; INHALED CAPSAICIN; NODOSE GANGLIA; RAT; MODULATION; AFFERENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Ramage, AG Univ Coll London, Dept Pharmacol, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Univ Coll London Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
Y. Wang e A.G. Ramage, "The role of central 5-HT1A receptors in the control of B-fibre cardiac andbronchoconstrictor vagal preganglionic neurones in anaesthetized cats", J PHYSL LON, 536(3), 2001, pp. 753-767

Abstract

1. Experiments were performed to determine whether 5-HT1A receptors (a) modulate the activity of cardiac and bronchoconstrictor vagal preganglionic neurones (CVPNS and BVPNS) in the nucleus ambiguus (NA) and (b) are involvedin pulmonary C-fibre afferent-evoked excitation of CVPNs, by right-atrial injections of phenylbiguanide (PBG). These experiments were carried out on alpha -chloralose-anaesthetized, artificially ventilated and atenolol (1 mgkg(-1))-pretreated cats.2. The ionophoretic application of 8-OH-DPAT (a selective 5-HT1A receptor agonist) influenced the activity of 16 of the 19 CVPNs tested. 8-OH-DPAT tended to cause inhibition at low currents (40 nA) and excitation at high currents (120 nA). The activity of 15 of these neurones increased in response to the application of 8-OH-DPAT. In six of the CVPNS tested, this excitatory action of 8-OH-DPAT was attenuated by co-application of the selective 5-HT1A receptor antagonist WAY-100635.3. The pulmonary C-fibre afferent-evoked excitation of eight CVPNS was attenuated by ionophoretic, application of WAY-100635.4. In three out of four CVPNs, the ionophoretic application of PBG caused excitation.5. In five out of the nine identified BVPNs that were tested with ionophoretic application of 8-OH-DPAT, excitation was observed that was attenuated by WAY-100635.6. WAY-100635 (I.V. or intra-cisternally) also reversed bradycardia, hypotension and the decrease in phrenic nerve activity evoked by the ix. application of 8-OH-DPAT (42 mug kg(-1)).7. In conclusion, the data indicate that 5-HT1A receptors located in the NA play an important role in the reflex activation of CVPNs and BVPNs, and support the view that overall, these receptors play a fundamental role in the reflex regulation of parasympathetic outflow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:24:08