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Titolo:
Electrochemistry at lipid monolayer-modified liquid-liquid interfaces as an improvement to drug partitioning studies
Autore:
Malkia, A; Liljeroth, P; Konturi, AK; Kontturi, K;
Indirizzi:
Helsinki Univ Technol, Phys Chem & Electrochem Lab, FIN-02015 Helsinki, Finland Helsinki Univ Technol Helsinki Finland FIN-02015 02015 Helsinki, Finland
Titolo Testata:
JOURNAL OF PHYSICAL CHEMISTRY B
fascicolo: 44, volume: 105, anno: 2001,
pagine: 10884 - 10892
SICI:
1520-6106(20011108)105:44<10884:EALMLI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCTYL ETHER INTERFACE; TETRAETHYLAMMONIUM ION TRANSFER; POLARIZATION PHENOMENA; TEMPERATURE-DEPENDENCE; BIOLOGICAL-MEMBRANES; IONIZABLE DRUGS; WATER; COEFFICIENTS; MODEL; ADSORPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kontturi, K Helsinki Univ Technol, Phys Chem & Electrochem Lab, POB 6100, FIN-02015 Helsinki, Finland Helsinki Univ Technol POB 6100 Helsinki Finland FIN-02015 and
Citazione:
A. Malkia et al., "Electrochemistry at lipid monolayer-modified liquid-liquid interfaces as an improvement to drug partitioning studies", J PHYS CH B, 105(44), 2001, pp. 10884-10892

Abstract

The drug partitioning between membrane and solution has traditionally beenapproached with bulk thermodynamic models, such as the octanol-water partitioning system. This neglects the orientational and compositional order in biological membranes. In the present study, electrochemistry at a Langmuir-Blodgett phospholipid monolayer-modified liquid-liquid interface has been employed to study the specific interactions between ionized drugs and phosphatidylcholine layers. To this end, AC voltammetric experiments and theoretical modeling accounting for the adsorption of the electroactive species have been carried out. The results point to a mechanism of charge transfer involving an adsorption step. This highlights the fact that in predicting biological activity of drugs, dynamic aspects and chemical interactions need tobe considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 16:11:53