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Titolo:
A multifrequency ESR study of the complex dynamics of membranes
Autore:
Lou, Y; Ge, MT; Freed, JR;
Indirizzi:
Cornell Univ, Baker Lab Chem & Chem Biol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 b Chem & Chem Biol, Ithaca, NY 14853 USA
Titolo Testata:
JOURNAL OF PHYSICAL CHEMISTRY B
fascicolo: 45, volume: 105, anno: 2001,
pagine: 11053 - 11056
SICI:
1520-6106(20011115)105:45<11053:AMESOT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-SPIN-RESONANCE; LOCAL-STRUCTURE MODEL; ROTATIONAL DIFFUSION; PHASE-EQUILIBRIA; HIGH-FREQUENCY; CHOLESTEROL; SPECTRA; MOTION; DIMYRISTOYLPHOSPHATIDYLCHOLINE; MULTILAYERS;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Freed, JR Cornell Univ, Baker Lab Chem & Chem Biol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 hem Biol, Ithaca, NY 14853 USA
Citazione:
Y. Lou et al., "A multifrequency ESR study of the complex dynamics of membranes", J PHYS CH B, 105(45), 2001, pp. 11053-11056

Abstract

A combined 250 and 9 GHz ESR study was performed on membrane vesicles composed of pure lipid (DPPC) and of DPPC:cholesterol in a 1:1 molar ratio using the end chain labeled lipid, 16-PC. It is shown that the 250 GHz spectra represent a " fast time-scale " such that the overall restricted motion of the lipid in the membrane is frozen out, but it is sensitive to the internal dynamics of the end chain. The 9 GHz spectra are, however, sensitive to the overall motion as well. This combined study thus permitted the separation of both types of motion. It is shown that the addition of cholesterol hasa large effect on the end chain dynamics by restricting its motion while increasing motional rates, whereas its effects on the overall lipid motion are modest. This leads to a clearer characterization of the dynamic structure of the cholesterol-rich liquid-ordered phase as compared to the liquid crystalline phase. This study thus shows the significant potential of a multifrequency ESR approach to the complex dynamics of membranes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:43:27