Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Skin pigmentation enhancers
Autore:
Brown, DA;
Indirizzi:
AGI Dermat, Freeport, NY 11520 USA AGI Dermat Freeport NY USA 11520AGI Dermat, Freeport, NY 11520 USA
Titolo Testata:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
fascicolo: 1-3, volume: 63, anno: 2001,
pagine: 148 - 161
SICI:
1011-1344(200110)63:1-3<148:SPE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; MELANOCYTE-STIMULATING HORMONE; GUINEA-PIG SKIN; CULTURED HUMAN MELANOCYTES; MESSENGER-RNA LEVELS; NITRIC-OXIDE; L-DOPA; ULTRAVIOLET-RADIATION; INDUCED MELANOGENESIS; MOUSE MELANOMA;
Keywords:
tanning; melanin; melanogenesis; pigmentation; photoprotection;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
172
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, DA AGI Dermat, 205 Buffalo Ave, Freeport, NY 11520 USA AGI Dermat 205 Buffalo Ave Freeport NY USA 11520 t, NY 11520 USA
Citazione:
D.A. Brown, "Skin pigmentation enhancers", J PHOTOCH B, 63(1-3), 2001, pp. 148-161

Abstract

The highest incidences of cancer are found in the skin, but endogenous pigmentation is associated with markedly reduced risk. Agents that enhance skin pigmentation have the potential to reduce both photodamage and skin cancer incidence. The purpose of this review is to evaluate agents that have thepotential to increase skin pigmentation. These include topically applied substances that simulate natural pigmentation: dihydroxyacetone and melanins; and substances that stimulate the natural pigmentation process: psoralenswith UVA (PUVA), dimethylsulfoxide (DMSO), L-tyrosine, L-Dopa, lysosomotropic agents, diacylglycerols, thymidine dinucleotides, DNA fragments, melanocyte stimulating hormone (MSH) analogs, 3-isobutyl-1-methylxanthine (IBMX),nitric oxide donors, and bicyclic monoterpene (BMT) diols. These agents are compared with regards to efficacy when administered to melanoma cells, normal human epidermal melanocytes, animal skin, and human skin. In addition,mechanisms of action are reviewed since these may reveal issues related toboth efficacy and safety. Both dihydroxyacetone and topically applied melanins are presently available to the consumer, and both of these have been shown to provide some photoprotection. Of the pigmentation stimulators, onlyPUVA and MSH analogs have been tested extensively on humans, but there areconcerns about the safety and side effects of both. At least some of the remaining pigmentation stimulators under development have the potential to safely induce a photoprotective tan. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:29:17