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Titolo:
Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxiceffects, and cytoprotective mechanisms
Autore:
Girotti, AW;
Indirizzi:
Med Coll Wisconsin, Dept Biochem, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 iochem, Milwaukee, WI 53226 USA
Titolo Testata:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
fascicolo: 1-3, volume: 63, anno: 2001,
pagine: 103 - 113
SICI:
1011-1344(200110)63:1-3<103:POOMLR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; PERFORMANCE LIQUID-CHROMATOGRAPHY; SINGLET MOLECULAR-OXYGEN; CHOLESTEROL PRODUCT ANALYSIS; HUMAN SKIN FIBROBLASTS; LEUKEMIA-CELLS; PHOTODYNAMIC-ACTION; BIOLOGICAL-SYSTEMS; FATTY-ACIDS; PHOSPHOLIPID HYDROPEROXIDES;
Keywords:
membranes; lipids; cholesterol; peroxidation; cytoprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Girotti, AW Med Coll Wisconsin, Dept Biochem, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 aukee, WI 53226 USA
Citazione:
A.W. Girotti, "Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxiceffects, and cytoprotective mechanisms", J PHOTOCH B, 63(1-3), 2001, pp. 103-113

Abstract

Unsaturated lipids in cell membranes, including phospholipids and cholesterol, are well-known targets of oxidative modification, which can be inducedby a variety of stresses, including ultraviolet A (UVA)- and visible light-induced photodynamic stress. Photodynamic lipid peroxidation has been associated with pathological conditions such as skin phototoxicity and carcinogenesis, as well as therapeutic treatments such as antitumor photodynamic therapy (PDT). Lipid hydroperoxides (LOOHs), including cholesterol hydroperoxides (ChOOHs), are important non-radical intermediates of the peroxidative process which can (i) serve as in situ reporters of type I vs. type II chemistry; (ii) undergo one-electron or two-electron reductive turnover which determines whether peroxidative injury is respectively intensified or suppressed, and (iii) mediate signaling cascades which either fortify antioxidantdefenses of cells or evoke apoptotic death if oxidative pressure is too great. The purpose of this article is to review current understanding of photodynamic (UVA- or visible light-induced) lipid peroxidation with a special focus on LOOH generation and reactivity. Future goals in this area, many ofwhich depend on continued development of state-of-the-art analytical techniques, will also be discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:38:03