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Titolo:
Individual variations in the correlation between erythemal threshold, UV-induced DNA damage and sun-burn cell formation
Autore:
Heenen, M; Giacomoni, PU; Golstein, P;
Indirizzi:
Free Univ Brussels, Hop Acad Erasme, Dept Dermatol, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 tol, B-1070 Brussels, Belgium Clin Labs, Melville, NY USA Clin Labs Melville NY USAClin Labs, Melville, NY USA
Titolo Testata:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
fascicolo: 1-3, volume: 63, anno: 2001,
pagine: 84 - 87
SICI:
1011-1344(200110)63:1-3<84:IVITCB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOBUTANE PYRIMIDINE DIMER; SKIN-CANCER RISK; NORMAL HUMANS; RADIATION; SUNSCREENS; SUNBURN; SENSITIVITY; PROTECTION; EXPOSURE; YIELDS;
Keywords:
UV; erythema; DNA damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Heenen, M Free Univ Brussels, Hop Acad Erasme, Dept Dermatol, 808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels 808 Route Lennik Brussels Belgium B-1070 ium
Citazione:
M. Heenen et al., "Individual variations in the correlation between erythemal threshold, UV-induced DNA damage and sun-burn cell formation", J PHOTOCH B, 63(1-3), 2001, pp. 84-87

Abstract

A linear correlation between erythema intensity and DNA damage upon exposure to UV has not been firmly established. Many of the deleterious effects of UV exposure do occur after exposure to suberythemal doses. After DNA damage, cells undergo DNA repair. It is commonly accepted that when the burden of damage is beyond the repair capacities, the cell undergoes programmed cell death or apoptosis. The aim of this study is to quantify the amount of UV-induced DNA damage (estimated via the measurement of DNA repair or unscheduled DNA synthesis or UDS) and cellular damage (estimated via the determination of the density of sunburn cells or SBC). If DNA damage and erythema are correlated, similar intensity of UDS and similar density of SBC should be found in volunteers irradiated with a UV dose equal to two minimal erythema doses (MED). Our results show that in 15 different individuals the same relative dose (2 MEDs) provokes UDS values, which vary within a factor of 4. An even larger variability affects SBC counts after the same relative dose. When DNA damage or SBC are plotted versus the absolute dose (i.e. the dose expressed in J/m(2)), there is a rough correlation (with several exceptions) between dose and extent of UDS and SBC counts. It seems possible to divide the volunteers into two subpopulations with different susceptibilitiesto UV damage. It is well known that UDS and SBC measurements are often affected by large experimental indeterminacy, yet, the analysis of our resultsmakes it plausible to suggest that for the triggering of erythema, a common threshold value for DNA damage or for SBC count are not to be found. In conclusion, the erythema response seems to be loosely correlated with DNA damage. This suggests that the protection offered by the sunscreens against DNA damage, the molecular basis of UV-induced mutagenesis, might not be related to the sun protection factor (SPF) indicated on the label of sunscreens, which is evaluated using the erythema as an endpoint. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:31:18