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Titolo:
Heat shock proteins in the photobiology of human skin
Autore:
Trautinger, F;
Indirizzi:
Univ Vienna, Div Special & Environm Dermatol, Dept Dermatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Dermatol, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
fascicolo: 1-3, volume: 63, anno: 2001,
pagine: 70 - 77
SICI:
1011-1344(200110)63:1-3<70:HSPITP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL HUMAN KERATINOCYTES; SUNBURN-CELL-FORMATION; ULTRAVIOLET-B LIGHT; OXIDATIVE STRESS; HEME OXYGENASE; EPIDERMAL-KERATINOCYTES; IN-VITRO; INCREASED EXPRESSION; LOCAL HYPERTHERMIA; CONFERS RESISTANCE;
Keywords:
stress proteins; apoptosis; keratinocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Trautinger, F Univ Vienna, Div Special & Environm Dermatol, Dept Dermatol,Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090
Citazione:
F. Trautinger, "Heat shock proteins in the photobiology of human skin", J PHOTOCH B, 63(1-3), 2001, pp. 70-77

Abstract

AU organisms respond to sudden environmental changes with the increased transcription of genes belonging to the family of heat shock proteins (hsps). Hsp-inducing stress factors include elevated temperatures, alcohol, heavy metals, oxidants, and agents leading to protein denaturation. The inductionof heat shock proteins is followed by a transient state of increased resistance to further stress and the heat shock response is generally thought torepresent an evolutionary conserved adaptive mechanism to cope with hostile environmental conditions. Since the skin as a barrier organ has to cope with the potentially harmful consequences of exposure to ultraviolet radiation (UV), it appears reasonable to question whether hsps constitute a natural defence mechanism against UV. Hsps have been detected in resting as well as in stressed epidermal and dermal cells and overexpression of hsps is associated with increased resistance to UV-induced cell death. Furthermore, UVitself is able to induce the expression of specific hsps. Thus, hsps mightprovide an adaptive cellular response to increasing UV and enhancing the expression of hsps might turn out as a new way to deal with the immediate and long-term consequences of UV exposure. Prerequisite for the utilization of this concept is the development of non-toxic heat shock inducers and their evaluation for clinical efficacy and safety. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/03/20 alle ore 08:28:56