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Titolo:
Solar UV irradiation and dermal photoaging
Autore:
Wlaschek, M; Tantcheva-Poor, I; Naderi, L; Ma, WJ; Schneider, A; Razi-Wolf, Z; Schuller, J; Scharffetter-Kochanek, K;
Indirizzi:
Univ Cologne, Dept Dermatol, D-50931 Cologne, Germany Univ Cologne Cologne Germany D-50931 Dermatol, D-50931 Cologne, Germany
Titolo Testata:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
fascicolo: 1-3, volume: 63, anno: 2001,
pagine: 41 - 51
SICI:
1011-1344(200110)63:1-3<41:SUIADP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRETINOIN RETINOIC ACID; HUMAN-SKIN FIBROBLASTS; MESSENGER-RNA LEVELS; A-INDUCED SYNTHESIS; INTERSTITIAL COLLAGENASE; HYDROGEN-PEROXIDE; SINGLET OXYGEN; MATRIX-METALLOPROTEINASES; CONNECTIVE-TISSUE; IN-VIVO;
Keywords:
connective tissue degradation; matrix-metalloproteases; photoaging; ultraviolet-irradiation; reactive oxygen species;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Scharffetter-Kochanek, K Univ Cologne, Dept Dermatol, Joseph Steizmann Str9, D-50931 Cologne, Germany Univ Cologne Joseph Steizmann Str 9 Cologne Germany D-50931
Citazione:
M. Wlaschek et al., "Solar UV irradiation and dermal photoaging", J PHOTOCH B, 63(1-3), 2001, pp. 41-51

Abstract

The skin is increasingly exposed to ambient UV-irradiation thus increasingrisks for photooxidative damage with long-term detrimental effects like photoaging, characterized by wrinkles, loss of skin tone and resilience. Photoaged skin displays alterations in the cellular component and extracellularmatrix with accumulation of disorganized elastin and its microfibrillar component fibrillin in the deep dermis and a severe loss of interstitial collagens, the major structural proteins of the dermal connective tissue. The unifying pathogenic agents for these changes are UV-generated reactive oxygen species (ROS) which deplete and damage non-enzymatic and enzymatic antioxidant defense systems of the skin. As well as causing permanent genetic changes, ROS activate cytoplasmic signal transduction pathways in resident fibroblasts that are related to growth, differentiation, senescence and connective tissue degradation. This review focuses on the role of UV-induced ROS in the photodamage of the skin resulting in clinical and biochemical characteristics of photoaging. In addition, the relationship of photoaging to intrinsic aging of the skin will be briefly discussed. A decrease in the overall ROS load by efficient sunscreens or other protective agents may represent promising strategies to prevent or at least minimize ROS-induced photoaging. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:01:55