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Titolo:
Imaging of blood flow and hypoxia in head and neck cancer: Initial evaluation with [O-15]H2O and [F-18]fluoroerythronitroimidazole PET
Autore:
Lehtio, K; Oikonen, V; Gronroos, T; Eskola, O; Kalliokoski, K; Bergman, J; Solin, O; Grenman, R; Nuutila, P; Minn, H;
Indirizzi:
Turku Univ, Turku PET Ctr, Cent Hosp, Medicity Res Lab, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 ity Res Lab, FIN-20521 Turku, Finland Turku Univ, Turku PET Ctr, Cent Hosp, Radiopharmaceut Chem Lab, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 ut Chem Lab, FIN-20521 Turku, Finland Turku Univ, Cent Hosp, Dept Radiotherapy & Oncol, FIN-20521 Turku, FinlandTurku Univ Turku Finland FIN-20521 apy & Oncol, FIN-20521 Turku, Finland Turku Univ, Cent Hosp, Dept Otorhinolaryngol Head & Neck Surg, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 & Neck Surg, FIN-20521 Turku, Finland
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 11, volume: 42, anno: 2001,
pagine: 1643 - 1652
SICI:
0161-5505(200111)42:11<1643:IOBFAH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; SQUAMOUS-CELL CARCINOMA; TUMOR HYPOXIA; F-18 FLUOROMISONIDAZOLE; GRAPHICAL ANALYSIS; SOLID TUMORS; RADIORESISTANCE; NITROIMIDAZOLES; RADIATION; PERFUSION;
Keywords:
[F-18]fluoroerythronitroimidazole; hypoxia; PET; head and neck cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Minn, H Turku Univ, Turku PET Ctr, Cent Hosp, Medicity Res Lab, POB 52, FIN-20521 Turku, Finland Turku Univ POB 52 Turku Finland FIN-20521 IN-20521 Turku, Finland
Citazione:
K. Lehtio et al., "Imaging of blood flow and hypoxia in head and neck cancer: Initial evaluation with [O-15]H2O and [F-18]fluoroerythronitroimidazole PET", J NUCL MED, 42(11), 2001, pp. 1643-1652

Abstract

Hypoxia is a characteristic feature of malignant tumors that should be evaluated before the start of therapy. F-18-labeled fluoroerythronitroimidazole (FETNIM) is a possible candidate for imaging tumor hypoxia with PET. Quantitative analysis of [F-18]FETNIM uptake in vivo is necessary before proceeding to assays predicting hypoxia. Methods: Eight patients with untreated head and neck squamous cell carcinoma were enrolled in the study. All patients underwent dynamic PET imaging with [F-18]FETNIM, coupled with measurements of blood flow with [O-15]H2O and blood volume with [O-15]CO. The metabolically active tumor volume was determined from [F-18]FDG PET performed on aseparate day. [F-18]FETNIM uptake in the tumor was correlated with that inneck muscles and arterial plasma and compared with the findings of other PET studies. Results: Blood flow in tumor was 5- to 30-fold greater than in muscle, in contrast to blood volume, which did not significantly differ in the 2 tissues. With [F-18]FETNIM PET, muscle activity remained invariably less than plasma activity, whereas activity in whole tumors was always greater than that in muscle. In 4 instances, the maximum tumor uptake of [F-18]FETNIM was 1.2-2.0 times higher than plasma activity in the late dynamic phase. A kinetic model developed for calculation of distribution volume of reversibly trapping tracers was successfully applied in the [F-18]FETNIM studies. Tumor distribution volume correlated strongly with the standardized uptake value of [F-18]FETNIM between 60 and 120 min and with blood flow but not with the standardized uptake value of [F-18]FDG. The relationship between[F-18]FETNIM uptake and the blood flow of the tumor was less obvious on a pixel-by-pixel level. Conclusion: Uptake of [F-18]FETNIM in head and neck cancer is highly variable and seems to be governed by blood flow at least inthe early phase of tissue accumulation. Maximum tumor-to-muscle tracer uptake ratios > 180 min were in the range of 1-4, comparing favorably with those reported previously for [F-18]fluoromisonidazole. Assessment of the distribution volume of [F-18]FETNIM the initial blood-flow phase is feasible for subsequent evaluation of hypoxia-specific retention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:53:37