Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Quantitative analysis of regional motion and thickening by gated myocardial perfusion SPECT: Normal heterogeneity and criteria for abnormality
Autore:
Sharir, T; Berman, DS; Waechter, PB; Areeda, J; Kavanagh, PB; Gerlach, J; Kang, XP; Germano, G;
Indirizzi:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA Cedars SinaiMed Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA Cedars Sinai MedCtr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA CSMC Burns & Allen Res Inst, Los Angeles, CA USA CSMC Burns & Allen Res Inst Los Angeles CA USA Inst, Los Angeles, CA USA Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA Dept Med, Los Angeles, CA USA Univ Calif Los Angeles, Sch Med, Dept Radiol Sci, Los Angeles, CA USA UnivCalif Los Angeles Los Angeles CA USA adiol Sci, Los Angeles, CA USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 11, volume: 42, anno: 2001,
pagine: 1630 - 1638
SICI:
0161-5505(200111)42:11<1630:QAORMA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY DISEASE; TC-99M SESTAMIBI; WALL-MOTION; DIMENSIONAL ECHOCARDIOGRAPHY; CONTRACTION ABNORMALITIES; VENTRICULAR-FUNCTION; VALIDATION; QUANTIFICATION; ALGORITHM;
Keywords:
gated SPECT; quantitation; motion; thickening;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Germano, G 8700 Beverly Blvd,Room A047N, Los Angeles, CA 90048 USA 8700 Beverly Blvd,Room A047N Los Angeles CA USA 90048 0048 USA
Citazione:
T. Sharir et al., "Quantitative analysis of regional motion and thickening by gated myocardial perfusion SPECT: Normal heterogeneity and criteria for abnormality", J NUCL MED, 42(11), 2001, pp. 1630-1638

Abstract

Quantitation of regional myocardial function is valuable in patients with coronary artery disease. This study assessed normal heterogeneity and developed and validated normal limits for quantitative regional motion and thickening by gated myocardial perfusion SPECT. Methods: Patients underwent rest(TI)-T-201/exercise Tc-99m-sestamibi gated SPECT. Reference values of motion and thickening for 20 myocardial segments were obtained in 105 patients with <5% likelihood of coronary disease (low-likelihood group). Criteria for abnormality of motion and thickening were defined for each segment, usingreceiver operator characteristic analysis, in 101 patients with coronary disease (training group). Semiquantitative visual interpretation was used asthe gold standard. These criteria were prospectively validated in 100 patients (validation group). Criteria for grading motion and thickening abnormalities by severity levels were also defined and validated. Results: Normal thickening decreased substantially along the longitudinal axis of the left ventricle, from 69% +/- 13% at the apex to 25% +/- 11 % at the basal segments, whereas normal motion varied within the same ventricular plane. Validation of the criteria for abnormality yielded high accuracy in the detection of motion abnormalities (sensitivity, 88%; specificity, 92%) and thickeningabnormalities (sensitivity, 87%; specificity, 89%). Quantitative motion and thickening segmental scores showed good agreement with visual scores. Conclusion: Normal regional myocardial contraction by gated myocardial perfusion SPECT is characterized by a substantial apex-to-base decline in thickening and by circumferential heterogeneity in endocardial motion. The assignment of segment-specific threshold values for defining motion and thickening abnormalities provided reasonably accurate identification and grading of regional myocardial dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 17:19:59