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Titolo:
Bcl-x(L) expression after contusion to the rat spinal cord
Autore:
Qiu, JX; Nesic, O; Ye, ZM; Rea, H; Westlund, KN; Xu, GY; McAdoo, D; Hulsebosch, CE; Perez-Polo, JR;
Indirizzi:
Univ Texas, Med Branch, Dept Human Biol Chem & Genet, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 l Chem & Genet, Galveston, TX 77550 USA Univ Texas, Med Branch, Dept Anat & Neurosci, Galveston, TX 77550 USA UnivTexas Galveston TX USA 77550 nat & Neurosci, Galveston, TX 77550 USA Univ Texas, Med Branch, Inst Marine Biomed, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 Marine Biomed, Galveston, TX 77550 USA
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 11, volume: 18, anno: 2001,
pagine: 1267 - 1278
SICI:
0897-7151(200111)18:11<1267:BEACTT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CASPASE-3 APOPTOTIC CASCADE; KAPPA-B ACTIVATION; BCL-2 HOMOLOG BAK; CELL-DEATH; PROTEIN EXPRESSION; GLOBAL-ISCHEMIA; X EXPRESSION; CHRONIC PAIN; DNA-DAMAGE; INJURY;
Keywords:
apoptosis; bcl-x; chronic central pain (CCP); spinal cord injury (SCI); spinothalamic tract (STT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Perez-Polo, JR 301 Univ Blvd, Galveston, TX 77555 USA 301 Univ Blvd Galveston TX USA 77555 lveston, TX 77555 USA
Citazione:
J.X. Qiu et al., "Bcl-x(L) expression after contusion to the rat spinal cord", J NEUROTRAU, 18(11), 2001, pp. 1267-1278

Abstract

After contusion-derived spinal cord injury, (SCI) there is localized tissue disruption and energy failure that results in early necrosis and delayed apoptosis, events that contribute to chronic central pain in a majority of patients. We assessed the extent of contusion-induced apoptosis of neurons in a known central pain-signaling pathway, the spinothalamic tract (STT), which may be a contributor to SCI-induced pain. We observed the loss of STT cells and localized increase of DNA fragmentation and cytoplasmic histone-DNA complexes, which suggested potential apoptotic changes among STT neuronsafter SCI. We also showed SCI-associated changes in the expression of the anti-apoptotic protein Bel-x(L), especially among STT cells, consistent with the hypothesis that Bcl-x(L) regulates the extent of apoptosis after SCI. Apoptosis in the injured spinal cord correlated well with prompt decreasesin Bcl-x(L) protein levels and Bcl-x(L)/Bax protein ratios at the contusion site. We interpret these results as evidence that regulation of Bcl-x(L) may play a role in neural sparing after spinal injury and pain-signaling function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 02:22:24