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Titolo:
A model of acute subdural hematoma in the mouse
Autore:
Sasaki, M; Dunn, L;
Indirizzi:
Nippon Med Sch 2nd Hosp, Dept Neurosurg, Kawasaki, Kanagawa, Japan Nippon Med Sch 2nd Hosp Kawasaki Kanagawa Japan awasaki, Kanagawa, Japan Inst Neurol Sci, Dept Neurosurg, Glasgow, Lanark, Scotland Inst Neurol Sci Glasgow Lanark Scotland osurg, Glasgow, Lanark, Scotland
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 11, volume: 18, anno: 2001,
pagine: 1241 - 1246
SICI:
0897-7151(200111)18:11<1241:AMOASH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC BRAIN-DAMAGE; TRANSGENIC MICE; APOLIPOPROTEIN-E; GLUTAMATE NEUROTOXICITY; GLUCOSE HYPERMETABOLISM; NMDA ANTAGONIST; IN-VIVO; RAT; INJURY; OVEREXPRESSION;
Keywords:
acute subdural hematoma; ischemic brain damage; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Dunn, L So Gen Hosp, Inst Neurol Sci, Dept Neurosurg, Glasgow G51 4TF, Lanark, Scotland So Gen Hosp Glasgow Lanark Scotland G51 4TF 4TF, Lanark, Scotland
Citazione:
M. Sasaki e L. Dunn, "A model of acute subdural hematoma in the mouse", J NEUROTRAU, 18(11), 2001, pp. 1241-1246

Abstract

The availability of genetically modified mice has allowed the study of genetic influences on acute brain injury. An animal model of acute subdural hematoma (ASDH) has been previously described in the rat but not the mouse. We describe a method for producing ASDH in the mouse. Subdural injections of50 and 30 muL of nonheparinized autologous blood were associated with excessive mortality. Injections of 10 and 20 muL were associated with mean percentage volumes of damage of 1.804% and 4.019%, respectively. Sham subdural injections of saline were associated with minimal hemisphere damage (0.152%). This mouse model provides a means of investigating the effects of genotype on the brain's response to ASDR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:41:33