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Titolo:
Expression of ciliary neurotrophic factor receptor in myasthenia gravis
Autore:
Poea, S; Guyon, T; Levasseur, P; Berrih-Aknin, S;
Indirizzi:
Hop Marie Lannelongue, CNRS, ESA 8078, Lab Physiol Thym, F-92350 Le Plessis Robinson, France Hop Marie Lannelongue Le Plessis Robinson France F-92350 obinson, France Hop Marie Lannelongue, Dept Chirurg Thorac, F-92350 Le Plessis Robinson, France Hop Marie Lannelongue Le Plessis Robinson France F-92350 obinson, France
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 120, anno: 2001,
pagine: 180 - 189
SICI:
0165-5728(20011101)120:1-2<180:EOCNFR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR; SKELETAL-MUSCLE; NEUROMUSCULAR-JUNCTION; GENE-EXPRESSION; SUBUNIT GENE; MESSENGER-RNA; EMBRYONIC MUSCLE; MYOGENIC FACTORS; SPINAL-CORD; ALPHA;
Keywords:
myasthenia gravis; CNTFR expression; muscle cells; AChR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Berrih-Aknin, S Hop Marie Lannelongue, CNRS, ESA 8078, Lab Physiol Thym, 133 Ave Resistance, F-92350 Le Plessis Robinson, France Hop Marie Lannelongue 133 Ave Resistance Le Plessis Robinson France F-92350
Citazione:
S. Poea et al., "Expression of ciliary neurotrophic factor receptor in myasthenia gravis", J NEUROIMM, 120(1-2), 2001, pp. 180-189

Abstract

In myasthenia gravis, high anti-nicotinic receptor (AChR) antibody titers are not always associated with severity of the disease, suggesting the involvement of other pathological effectors. We showed that ciliary neurotrophic factor receptor (CNTFR) gene expression was higher in muscle biopsy tissue from. severely affected MG patients regardless of anti-nAChR antibody titer. This increase was also triggered in vitro by a seric factor from MG patients. CNTFR protein expression was decreased in muscles from seropositive MG patients only. Altogether, our data indicate that the alteration of CNTFR expression in some MG patients could contribute to the severity of the disease in a subgroup of patients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:40:32