Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Behavioural stress blunts the creatinine clearance increase induced by a protein load in healthy subjects
Autore:
Centonza, L; Castoldi, G; Busca, G; Stella, A; Zanchetti, A; Golin, R;
Indirizzi:
Univ Milan, Ctr Fisiol Clin & Ipertens, Osped Maggiore, Inst Gen Med, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 giore, Inst Gen Med, I-20122 Milan, Italy
Titolo Testata:
JOURNAL OF NEPHROLOGY
fascicolo: 5, volume: 14, anno: 2001,
pagine: 403 - 409
SICI:
1121-8428(200109/10)14:5<403:BSBTCC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-FUNCTION; DIETARY-PROTEIN; GLOMERULAR HYPERFILTRATION; ARTERIAL-PRESSURE; RENIN RELEASE; MENTAL STRESS; HYPERTENSION; HUMANS; SODIUM; HEMODYNAMICS;
Keywords:
glomerular filtration rate; renal functional reserve; behavioural stress; protein load; healthy subjects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Golin, R Univ Milan, Ctr Fisiol Clin & Ipertens, Osped Maggiore, Inst Gen Med, Via F Sforza 35, I-20122 Milan, Italy Univ Milan Via F Sforza 35 Milan Italy I-20122 0122 Milan, Italy
Citazione:
L. Centonza et al., "Behavioural stress blunts the creatinine clearance increase induced by a protein load in healthy subjects", J NEPHROL, 14(5), 2001, pp. 403-409

Abstract

Background: The aim of this study was to investigate how behavioural states related to different levels of stress affected the increments of glomerular filtration rate induced by an acute protein load. Methods: Thirteen healthy subjects were enrolled. Each subject was studiedfrom 9:00 h to 15:00 h on two consecutive days. In random order, after a protein meal (1.2 g/kg b.w. of protein), each subject was required to remainin a relaxing, sitting position (resting period, R), or to solve graphicaland mathematical problems (behavioural stress period, S). Mean blood pressure (MBP) and heart rate (HR) were monitored by an ambulatory blood pressure device. Urine samples collected in each period were used to measure glomerular filtration rate (GFR, creatinine clearance) and urinary sodium excretion (UNa+V). Results: Significant decreases in MBP and HR were observed during the resting period after the protein load, which significantly increased GER. Therewas also a large increase of UNa+V. During S, the GFR changes were no longer seen whereas the increse of UNa+V was maintained HR and MBP did not change compared to the prestimulus period. Conclusions: We conclude that in healthy subjects behavioural stress can blunt the increase in GFR that follows a protein load, presumably by neuro-humoral activated mechanisms. In our experimental conditions, behavioural stress did not affect UNa+V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:35:44