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Titolo:
Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and A beta immunization
Autore:
Schenk, D; Games, D; Seubert, P;
Indirizzi:
Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut S San Francisco CA USA 94080 San Francisco, CA 94080 USA
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 2, volume: 17, anno: 2001,
pagine: 259 - 267
SICI:
0895-8696(200110)17:2<259:PTOFAD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; TRANSGENIC MICE; PEPTIDE IMMUNIZATION; PATHOLOGY; PRESENILIN-1; MUTATION; CLEAVAGE; GENE; AGGREGATION; PLAQUES;
Keywords:
Alzheimer's disease; beta amyloid; beta secretase; gamma secretase; immunization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Schenk, D Elan Pharmaceut, 800 Gate Blvd, S San Francisco, CA 94080 USA Elan Pharmaceut 800 Gate Blvd S San Francisco CA USA 94080 0 USA
Citazione:
D. Schenk et al., "Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and A beta immunization", J MOL NEURO, 17(2), 2001, pp. 259-267

Abstract

Research over the past ten years on Alzheimer's disease has pursued many opportunities. Notable amongst the various approaches are efforts related tothe "amyloid hypothesis. " This hypothesis posits that the beta amyloid pepticle causes the extensive neuropathology and clinical decline associated with the disease. Extensive research in this area has shown that the beta amyloid peptide is produced by proteases termed "secretases" and it has been shown that blockade of secretase functions reduce the amount of beta amyloid peptide produced. An additional approach to reduce beta amyloid, through an increase in clearance mechanisms, is to immunize with the peptide itselfand induce an antibody response. The specifically elicited antibodies thenbind to and stimulate clearance of the pepticle from the brain. These findings have stimulated several approaches to develop novel therapeutic strategies to treat Alzheimer's disease that either are about or have entered theclinic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:29:22