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Titolo:
Nuclear signaling - A common function of presenilin substrates?
Autore:
Steiner, H; Haass, C;
Indirizzi:
Univ Munich, Adolf Butenandt Inst, Dept Biochem, Lab Alzheimers & Parkinsons Dis Res, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 sons Dis Res, D-80336 Munich, Germany
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 2, volume: 17, anno: 2001,
pagine: 193 - 198
SICI:
0895-8696(200110)17:2<193:NS-ACF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; GAMMA-SECRETASE ACTIVITY; PHOSPHOTYROSINE-BINDING DOMAIN; INTRACELLULAR DOMAIN; DISINTEGRIN-METALLOPROTEASE; IN-VIVO; NOTCH; CLEAVAGE; ENDOPROTEOLYSIS; PROTEOLYSIS;
Keywords:
Alzheimer's disease; beta APP; presenilin; AICD; NICD; Notch;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Haass, C Univ Munich, Adolf Butenandt Inst, Dept Biochem, Lab Alzheimers &Parkinsons Dis Res, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 Res, D-80336 Munich, Germany
Citazione:
H. Steiner e C. Haass, "Nuclear signaling - A common function of presenilin substrates?", J MOL NEURO, 17(2), 2001, pp. 193-198

Abstract

Major progress has recently been made in the characterization of the secretases involved in endoproteolytic processing of the Alzheimer's disease (AD)-associated beta -amyloid precursor protein, beta APP. beta APP is the precursor of the amyloid beta -peptide, which is a major constituent of amyloid plaques in the brains of Alzheimer patients. It is now commonly believed that A beta plays a pivotal role in the pathogenesis of AD, and that inhibiting the production of A beta may help to treat or to prevent the disease. With beta -secretase and the presenilins, two essential factors in the proteolytic generation of A beta have now been identified. However, very littleis still known about the biological function of the long-known beta APP. In this review we will discuss a novel putative function of beta APP in nuclear signaling, an activity, that beta APP may share with other presenilin substrates such as Notch.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:17:25