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Titolo:
Metabolism of presenilins
Autore:
Thinakaran, G;
Indirizzi:
Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Ctr Mol Neurobiol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 tr Mol Neurobiol, Chicago, IL 60637 USA
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 2, volume: 17, anno: 2001,
pagine: 183 - 192
SICI:
0895-8696(200110)17:2<183:MOP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE-ASSOCIATED PRESENILIN-1; GAMMA-SECRETASE ACTIVITY; AMYLOID BETA-PROTEIN; ALZHEIMERS-DISEASE; NEURONAL DIFFERENTIATION; TERMINAL FRAGMENTS; TRANSFECTED CELLS; ENDOPROTEOLYTIC CLEAVAGE; TRANSMEMBRANE ASPARTATES; MUTANT PRESENILIN-2;
Keywords:
presenilin; PS1; PS2; familial Alzheimer's disease; proteolysis; amyloid precursor protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Thinakaran, G Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Ctr Mol Neurobiol, KnappR212,924 E 57th St, Chicago, IL 60637 USA Univ Chicago Knapp R212,924 E 57th St Chicago IL USA 60637 A
Citazione:
G. Thinakaran, "Metabolism of presenilins", J MOL NEURO, 17(2), 2001, pp. 183-192

Abstract

Understanding mechanisms involved in the production of A beta has long been the central focus of cell biologists engaged in molecular AD research. The discovery of two genes that encode homologous polytopic membrane proteinstermed Presenilins (PS), has lead to several exciting recent findings on the proteolytic processes responsible for generating the COOH-terminus of A beta. What we now know is that PS proteins play an important role in A betaproduction and are considered one of the therapeutic targets. Here I have reviewed the vast literature on the biology of PS, especially focusing on PS endoproteolysis and the accumulation of stable PS derivatives that are likely the functional units.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:19:07