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Titolo:
Pathologic correlates of nondemented aging, mild cognitive impairment, andearly-stage Alzheimer's disease
Autore:
Morris, JC; Price, JL;
Indirizzi:
Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63108 USA Washington Univ St Louis MO USA 63108 Dept Neurol, St Louis, MO 63108 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63108 USA Washington Univ St Louis MO USA 63108 l & Immunol, St Louis, MO 63108 USA Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63108 USA Washington Univ St Louis MO USA 63108 & Neurobiol, St Louis, MO 63108 USA Washington Univ, Sch Med, Alzheimer Dis Res Ctr, St Louis, MO 63108 USA Washington Univ St Louis MO USA 63108 Dis Res Ctr, St Louis, MO 63108 USA
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 2, volume: 17, anno: 2001,
pagine: 101 - 118
SICI:
0895-8696(200110)17:2<101:PCONAM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; DIFFERENT AGE CATEGORIES; MINI-MENTAL-STATE; NEUROFIBRILLARY TANGLES; MEMORY IMPAIRMENT; OLDER ADULTS; ELDERLY POPULATION; DEMENTIA SEVERITY; PRECLINICAL PHASE; FRAMINGHAM COHORT;
Keywords:
aging; mild cognitive impairment; Alzheimer's disease; amyloid plaques;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Morris, JC Washington Univ, Sch Med, Dept Neurol, 4488 Forest Pk Ave,Suite130, St Louis, MO 63108 USA Washington Univ 4488 Forest Pk Ave,Suite 130 St Louis MO USA 63108
Citazione:
J.C. Morris e J.L. Price, "Pathologic correlates of nondemented aging, mild cognitive impairment, andearly-stage Alzheimer's disease", J MOL NEURO, 17(2), 2001, pp. 101-118

Abstract

The results of studies from the Washington University Alzheimer Disease (AD) Research Center and those from other centers and investigators regardingthe neuropathologic correlates of normal aging and early-stage AD are reviewed. We conclude that widespread amyloid plaques in the neocortex best distinguishes very early stage AD, including "MCI" stage, and preclinical stages, from healthy brain aging. Other AD lesions, including increased formation of neurofibrillary tangles and neuronal degeneration appear to result from the amyloid-initiated pathologic process, although they may have a more immediate effect on expression and severity of dementia. These data providestrong support for anti-amyloid intervention as a preventive therapy for AD. It is now critical to develop methods to detect preclinical AD during life.

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Documento generato il 23/01/20 alle ore 12:32:37