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Titolo:
Evolution of the Rab family of small GTP-binding proteins
Autore:
Pereira-Liel, JB; Seabra, MC;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Biomed Sci, Cell& Mol Biol Sect, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med London England SW7 2AZ gland
Titolo Testata:
JOURNAL OF MOLECULAR BIOLOGY
fascicolo: 4, volume: 313, anno: 2001,
pagine: 889 - 901
SICI:
0022-2836(20011102)313:4<889:EOTRFO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; EPITHELIAL-CELLS; SUBCELLULAR-LOCALIZATION; NUCLEOTIDE EXCHANGE; RECYCLING ENDOSOMES; VESICULAR TRANSPORT; SEQUENCE ALIGNMENT; SECRETORY GRANULES; ENDOCYTIC PATHWAY; MEMBRANE-FUSION;
Keywords:
Rab proteins; GTPases; evolution; annotation; identification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Pereira-Liel, JB Univ London Imperial Coll Sci Technol & Med, Fac Med, DivBiomed Sci, Cell& Mol Biol Sect, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med London England SW7 2AZ
Citazione:
J.B. Pereira-Liel e M.C. Seabra, "Evolution of the Rab family of small GTP-binding proteins", J MOL BIOL, 313(4), 2001, pp. 889-901

Abstract

Rab proteins are small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane-associated molecular switches. Here, we have identified the complete Rab families in the Caenorhabditis elegans (29 members), Drosophila melanogaster (29), Homo sapiens (60) and Arabidopsis thaliana(57), and we defined criteria for annotation of this protein family in each organism. We studied sequence conservation patterns and observed that theRabF motifs and the RabSF regions previously described in mammalian Rabs are conserved across species. This is consistent with conserved recognition mechanisms by general regulators and specific effectors. We used phylogenetic analysis and other approaches to reconstruct the multiplication of the Rab family and observed that this family shows a strict phylogeny of function as opposed to a phylogeny of species. Furthermore, we observed that Rabs co-segregating in phylogenetic trees show a pattern of similar cellular localisation and/or function. Therefore, animal and fungi Rab proteins can be grouped in "Rab functional groups" according to their segregating patterns in phylogenetic trees. These functional groups reflect similarity of sequence, localisation. and/or function, and may also represent shared ancestry. Rab functional groups can help the understanding of the functional evolution of the Rab family in particular and vesicular transport in general, and may be used to predict general functions for novel Rab sequences. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:34:59