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Titolo:
Role of Src kinases and Syk in Fc gamma receptor-mediated phagocytosis andphagosome-lysosome fusion
Autore:
Majeed, M; Caveggion, E; Lowell, CA; Berton, G;
Indirizzi:
Univ Verona, Dept Pathol, Sect Gen Pathol, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 Sect Gen Pathol, I-37100 Verona, Italy Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 5, volume: 70, anno: 2001,
pagine: 801 - 811
SICI:
0741-5400(200111)70:5<801:ROSKAS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; CELL ANTIGEN-RECEPTOR; SIGNAL-TRANSDUCTION; HUMAN NEUTROPHILS; FAMILY KINASES; MYCOBACTERIUM-TUBERCULOSIS; FUNCTIONAL ASSOCIATION; HUMAN MONOCYTES; C-SRC; MACROPHAGES;
Keywords:
protein tyrosine phosphorylation; immune receptors; signal transduction; Fyn; Yes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Majeed, M Linkoping Univ, Fac Hlth Sci, Dept Hlth & Environm, Div Med Microbiol, SE-58185 Linkoping, Sweden Linkoping Univ Linkoping Sweden SE-58185 185 Linkoping, Sweden
Citazione:
M. Majeed et al., "Role of Src kinases and Syk in Fc gamma receptor-mediated phagocytosis andphagosome-lysosome fusion", J LEUK BIOL, 70(5), 2001, pp. 801-811

Abstract

Phagocytosis is increased by Fc gamma receptors (Fc gamma Rs), and studieswith syk(-/-) macrophages demonstrated that Syk kinase is required for Fc gammaR phagocytosis. Similar studies with macrophages lacking the Src family kinases Hck, Fgr, and Lyn showed that these kinases are not required for phagocytosis but that they enhance the rate of particle engulfment. In thisreport we show that both wild-type and hck(-/-) fgr(-/-) macrophages expressed Fyn, Src, and Yes and that these kinases were activated on ingestion of immunoglobulin G (IgG)-coated particles and redistributed, together with Syk, to actin-rich phagocytic cups and the phagosomal membrane. At doses blocking IgG-dependent phagocytosis, the tyrosine kinase inhibitors PP1 and piceatannol inhibited both Src family kinase and Syk activities, as well as their redistribution to actin-rich phagocytic cups. Hck, Fgr, and Lyn were dispensable for lysosome-phagosome fusion (PLF) induced by IgG-coated particles. However, PP1 or piceatannol hampered unopsonized yeast-induced PLF despite the fact that they did not block yeast internalization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 00:25:44